Increasing incidence of early-onset colorectal cancer

FA Sinicrope - New England Journal of Medicine, 2022 - Mass Medical Soc
Early-Onset Colorectal Cancer Early-onset disease (at< 50 years of age) accounts for 10%
of colorectal cancer cases, and the incidence is increasing, particularly in high-income …

Is early-onset cancer an emerging global epidemic? Current evidence and future implications

T Ugai, N Sasamoto, HY Lee, M Ando… - Nature Reviews …, 2022 - nature.com
Over the past several decades, the incidence of early-onset cancers, often defined as
cancers diagnosed in adults< 50 years of age, in the breast, colorectum, endometrium …

Colorectal cancer statistics, 2023

RL Siegel, NS Wagle, A Cercek… - CA: a cancer journal …, 2023 - Wiley Online Library
Colorectal cancer (CRC) is the second most common cause of cancer death in the United
States. Every 3 years, the American Cancer Society provides an update of CRC statistics …

Inflammation: the incubator of the tumor microenvironment

D Denk, FR Greten - Trends in Cancer, 2022 - cell.com
An inflammatory microenvironment, either conferred by an underlying chronic overt or
smoldering inflammatory condition constitutes a prerequisite and fuel to essentially all …

[PDF][PDF] Health effects of the use of non-sugar sweeteners: a systematic review and meta-analysis

M Rios-Leyvraz, J Montez, World Health Organization - 2022 - apps.who.int
Executive summary A 2019 systematic review on intake of non-sugar sweeteners (NSS) in
adults and children was updated and expanded to include studies in which NSS were not …

The rising tide of early-onset colorectal cancer: a comprehensive review of epidemiology, clinical features, biology, risk factors, prevention, and early detection

SG Patel, JJ Karlitz, T Yen, CH Lieu… - The lancet …, 2022 - thelancet.com
The incidence of early-onset colorectal—ie, colorectal cancer cancer diagnosed in patients
under the age of 50 years—has been increasing around the world. This Series paper …

[HTML][HTML] Delphi initiative for early-onset colorectal cancer (DIRECt) international management guidelines

GM Cavestro, A Mannucci, F Balaguer… - Clinical …, 2023 - Elsevier
Background & Aims Patients with early-onset colorectal cancer (eoCRC) are managed
according to guidelines that are not age-specific. A multidisciplinary international group …

Intake of ultra-processed foods is associated with an increased risk of Crohn's disease: a cross-sectional and prospective analysis of 187 154 participants in the UK …

J Chen, J Wellens, R Kalla, T Fu, M Deng… - Journal of Crohn's …, 2023 - academic.oup.com
Abstract Background and Aims Ultra-processed food [UPF] consumption has been linked to
globally increasing incidence and prevalence of chronic diseases, including inflammatory …

[HTML][HTML] Epidemiology and biology of early onset colorectal cancer

A Venugopal, JM Carethers - EXCLI journal, 2022 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is the third leading cause of cancer-related mortality in men or
women in the United States. Average-risk screening that begins at age 50 years has …

Diet and gut microbiome in gastrointestinal disease

GL Trakman, S Fehily, C Basnayake… - Journal of …, 2022 - Wiley Online Library
The composition and function of the dynamic microbial community that constitutes the gut
microbiome is continuously shaped by the host genome, mode of birth delivery, geography …