The Ets1 proto-oncoprotein is a member of the Ets family of transcription factors that share a
unique DNA binding domain, the Ets domain. The DNA binding activity of Ets1 is controlled …

Carcinogenesis is a multi-step process which could be prevented by phytochemicals.
Phytochemicals from dietary plants and other plant sources such as herbs are becoming …

Abstract Tumor-initiating cells (TIC), also known as cancer stem cells, are regarded widely
as a specific subpopulation of cells needed for cancer initiation and progression. TICs have …

Invasive and metastatic cells, as well as endothelial cells, must cross basement membranes
(BMs) in order to disseminate or to form new blood vessels. The chemoinvasion assay using …

Vascular endothelial growth factor (VEGF) plays a crucial role in angiogenesis of many solid
malignancies. The influence of angiogenesis and VEGF expression on progression and …

The protein kinase family, one of the largest gene families in eukaryotes, plays an important
role in regulating various cellular processes such as cell proliferation, cell death, cell cycle …

Endoglin (CD105), a member of transforming growth factor β1 receptor complex, has been
shown to be a more useful marker to identify tumor angiogenesis than panendothelial …

Background: VEGF is a prime mediator of tumorigenesis and metastasis. Various studies
assessing the prognostic value of VEGF in patients with esophageal cancer remain …

ETS1 has shown dichotomous roles as an oncogene and a tumor suppressor gene in
diverse cancers, but its functionality in breast cancer tumorigenesis still remains unclear. We …

Expression of the transcription factor Ets‐1 is increasingly associated with the progression of
several human cancers. A tumor‐derived factor is expected to be involved in the …