T cell receptor (TCR) signaling in health and disease
Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in
changes at the molecular and cellular levels in T cells. The outside environmental cues are …
changes at the molecular and cellular levels in T cells. The outside environmental cues are …
Aging, inflammaging and immunosenescence as risk factors of severe COVID-19
AM Tizazu, HM Mengist, G Demeke - Immunity & Ageing, 2022 - Springer
Abstract Coronavirus disease 2019 (COVID-19) is a respiratory infectious disease caused
by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is …
by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is …
The dietary sweetener sucralose is a negative modulator of T cell-mediated responses
Artificial sweeteners are used as calorie-free sugar substitutes in many food products and
their consumption has increased substantially over the past years. Although generally …
their consumption has increased substantially over the past years. Although generally …
Improving CAR T-cell persistence
V Pietrobon, LA Todd, A Goswami, O Stefanson… - International journal of …, 2021 - mdpi.com
Over the last decade remarkable progress has been made in enhancing the efficacy of CAR
T therapies. However, the clinical benefits are still limited, especially in solid tumors. Even in …
T therapies. However, the clinical benefits are still limited, especially in solid tumors. Even in …
Adoptive cellular immunotherapy for solid neoplasms beyond CAR-T
In recent decades, immune checkpoint blockade and chimeric antigen receptor T cell (CAR-
T) therapy are two milestone achievements in clinical immunotherapy. However, both show …
T) therapy are two milestone achievements in clinical immunotherapy. However, both show …
T cell cholesterol efflux suppresses apoptosis and senescence and increases atherosclerosis in middle aged mice
Atherosclerosis is a chronic inflammatory disease driven by hypercholesterolemia. During
aging, T cells accumulate cholesterol, potentially affecting inflammation. However, the effect …
aging, T cells accumulate cholesterol, potentially affecting inflammation. However, the effect …
[HTML][HTML] Regulatory role of zinc in immune cell signaling
B Kim, WW Lee - Molecules and cells, 2021 - Elsevier
Zinc is an essential micronutrient with crucial roles in multiple facets of biological processes.
Dysregulated zinc homeostasis impairs overall immune function and resultantly increases …
Dysregulated zinc homeostasis impairs overall immune function and resultantly increases …
Phosphoinositide acyl chain saturation drives CD8+ effector T cell signaling and function
J Edwards-Hicks, P Apostolova, JM Buescher… - Nature …, 2023 - nature.com
How lipidome changes support CD8+ effector T (Teff) cell differentiation is not well
understood. Here we show that, although naive T cells are rich in polyunsaturated …
understood. Here we show that, although naive T cells are rich in polyunsaturated …
TCR ligand potency differentially impacts PD-1 inhibitory effects on diverse signaling pathways
Checkpoint blockade revolutionized cancer therapy, but we still lack a quantitative,
mechanistic understanding of how inhibitory receptors affect diverse signaling pathways. To …
mechanistic understanding of how inhibitory receptors affect diverse signaling pathways. To …
Resident regulatory T cells reflect the immune history of individual lymph nodes
Regulatory T cells (Tregs) are present in lymphoid and nonlymphoid tissues where they
restrict immune activation, prevent autoimmunity, and regulate inflammation. Tregs in …
restrict immune activation, prevent autoimmunity, and regulate inflammation. Tregs in …