TCR ligand potency differentially impacts PD-1 inhibitory effects on diverse signaling pathways
Checkpoint blockade revolutionized cancer therapy, but we still lack a quantitative,
mechanistic understanding of how inhibitory receptors affect diverse signaling pathways. To …
mechanistic understanding of how inhibitory receptors affect diverse signaling pathways. To …
Engaging natural killer cells for cancer therapy via NKG2D, CD16A and other receptors
KA Whalen, K Rakhra, NK Mehta, A Steinle… - MAbs, 2023 - Taylor & Francis
The field of immuno-oncology has revolutionized cancer patient care and improved survival
and quality of life for patients. Much of the focus in the field has been on exploiting the power …
and quality of life for patients. Much of the focus in the field has been on exploiting the power …
T-cell engaging poly (lactic-co-glycolic acid) nanoparticles as a modular platform to induce a potent cytotoxic immunogenic response against PD-L1 overexpressing …
Bispecific nanoparticles (NPs) are conjugated with two antibodies that enhance T cell
cytotoxicity by sequentially targeting CD3 and tumor-specific proteins. This interaction …
cytotoxicity by sequentially targeting CD3 and tumor-specific proteins. This interaction …
[HTML][HTML] Production and characterization of virus-free, CRISPR-CAR T cells capable of inducing solid tumor regression
Background Chimeric antigen receptor (CAR) T cells have demonstrated high clinical
response rates against hematological malignancies (eg, CD19+ cancers) but have shown …
response rates against hematological malignancies (eg, CD19+ cancers) but have shown …
Precise surface functionalization of PLGA particles for human T cell modulation
The biofunctionalization of synthetic materials has extensive utility for biomedical
applications, but approaches to bioconjugation typically show insufficient efficiency and …
applications, but approaches to bioconjugation typically show insufficient efficiency and …
T cell receptor signaling in the differentiation and plasticity of CD4+ T cells
CD4+ T cells are critical components of the adaptive immune system. The T cell receptor
(TCR) and co-receptor signaling cascades shape the phenotype and functions of CD4+ T …
(TCR) and co-receptor signaling cascades shape the phenotype and functions of CD4+ T …
[HTML][HTML] Coreceptors and TCR signaling–the strong and the weak of it
The T-cell coreceptors CD4 and CD8 have well-characterized and essential roles in thymic
development, but how they contribute to immune responses in the periphery is unclear …
development, but how they contribute to immune responses in the periphery is unclear …
Thioamide Analogues of MHC I Antigen Peptides
R Gibadullin, RK Morris, J Niu, J Sidney… - Journal of the …, 2023 - ACS Publications
Short, synthetic peptides that are displayed by major histocompatibility complex I (MHC I)
can stimulate CD8 T cells in vivo to destroy virus-infected or cancer cells. The development …
can stimulate CD8 T cells in vivo to destroy virus-infected or cancer cells. The development …
Proliferative exhausted CD8+ T cells exacerbate long-lasting anti-tumor effects in human papillomavirus-positive head and neck squamous cell carcinoma
D Cheng, K Qiu, Y Rao, M Mao, L Li, Y Wang, Y Song… - Elife, 2023 - elifesciences.org
The survival prognosis of human papillomavirus (HPV)-positive and HPV-negative head and
neck squamous cell carcinoma (HNSCC) is largely different, and little is known about the …
neck squamous cell carcinoma (HNSCC) is largely different, and little is known about the …
[HTML][HTML] A multiple-oscillator mechanism underlies antigen-induced Ca2+ oscillations in Jurkat T-cells
JC Benson, O Romito, AE Abdelnaby, P Xin… - Journal of Biological …, 2023 - ASBMB
T-cell receptor stimulation triggers cytosolic Ca 2+ signaling by inositol-1, 4, 5-trisphosphate
(IP 3)-mediated Ca 2+ release from the endoplasmic reticulum (ER) and Ca 2+ entry through …
(IP 3)-mediated Ca 2+ release from the endoplasmic reticulum (ER) and Ca 2+ entry through …