T cell activation is a critical event in the adaptive immune response, indispensable for cell-
mediated and humoral immunity as well as for immune regulation. Recent years have …

Allogeneic hematopoietic stem cell transplantation (allo-HCT) is a potentially curative
therapy for patients suffering from hematological malignancies via the donor immune system …

Relapse and refractory T-cell acute lymphoblastic leukemia (T-ALL) has a poor prognosis,
and new combination therapies are sorely needed. Here, we used an ex vivo high …

The lack of an efficient method for the identification of tumor antigen-specific T cell receptors
(TCRs) impedes the development of T cell-based cancer immunotherapies. Here, we …

Inflammatory reactions are part of a complex biological response that plays a vital role in the
appearance of various stimuli resulting from tissue and cell damage, the invasion of …

Chimeric antigen receptor T (CAR-T) cell therapy has drawn increasing attention over the
last few decades given its remarkable effectiveness and breakthroughs in treating B cell …

Gene transfer with high doses of adeno-associated viral (AAV) vectors has resulted in
serious adverse events and even death of the recipients. Toxicity could most likely be …

Once administrated, intercellular adhesion to recognize and/or arrest target cells is essential
for specific treatments, especially for cancer or tumor. However, immune cells administrated …

Immunological memory is the underlying mechanism by which the immune system
remembers previous encounters with pathogens to produce an enhanced secondary …

The breast cancer tumor microenvironment (TME) is dynamic, with various immune and non-
immune cells interacting to regulate tumor progression and anti-tumor immunity. It is now …