The gut microbiota plays an important role in regulating the host immune systems. It is well
established that various commensal microbial species can induce the differentiation of …

Background Despite significant advances in cancer immunotherapy over the past decades,
such as T cell-engaging chimeric antigen receptor (CAR)-T cell therapy and immune …

A synthetic circuit in a biological system involves the designed assembly of genetic
elements, biomolecules, or cells to create a defined function. These circuits are central in …

Bidirectional cross-talk between commensal microbiota and the immune system is essential
for the regulation of immune responses and the formation of immunological memory …

CD8+ T cells play important roles in immunity and immuno-oncology. Upon antigen
recognition and co-stimulation, naïve CD8+ T cells escape from dormancy to engage in a …

Motivation Deep learning techniques have yielded tremendous progress in the field of
computational biology over the last decade, however many of these techniques are opaque …

Immune thrombocytopenia is a common heterogeneous autoimmune disease that is
characterized by decreasing peripheral blood platelet counts and increasing risk of …

(1) Background: six mammalian ceramide synthases (CerS1–6) determine the acyl chain
length of sphingolipids (SLs). Although ceramide levels are increased in murine allergic …

As an atypical member of the Rho family small GTPases, RhoH shares less than 50%
sequence similarity with other members, and its expression is commonly observed in the …

The immune system has emerged as an important target of thyroid hormones (THs);
however, the role of TH in T cells has so far remained elusive. In this study, we assessed the …