Aging is driven by hallmarks fulfilling the following three premises:(1) their age-associated
manifestation,(2) the acceleration of aging by experimentally accentuating them, and (3) the …

Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Rationale: Vascular smooth muscle cell (VSMC) senescence promotes atherosclerosis and
features of plaque instability, in part, through lipid-mediated oxidative DNA damage and …

The morbidity and mortality of autoimmune diseases (Ads) have been increasing worldwide,
and the identification of novel therapeutic strategies for prevention and treatment is urgently …

The thymus is the primary immune organ responsible for generating self‐tolerant and
immunocompetent T cells. However, the thymus gradually involutes during early life …

Sirtuins are NAD+-dependent deacetylase and deacylase enzymes that control important
cellular processes, including DNA damage repair, cellular metabolism, mitochondrial …

Nonalcoholic fatty liver disease (NAFLD) is characterized by excessive hepatic lipid
accumulation, which can progress to nonalcoholic steatohepatitis (NASH). Histone …

Allostery, which is one of the most direct and efficient methods to fine-tune protein functions,
has gained increasing recognition in drug discovery. However, there are several challenges …

The biological functions of sirtuin 6 (SIRT6; eg, deacetylation, defatty‐acylation, and mono‐
ADP‐ribosylation) play a pivotal role in regulating lifespan and several fundamental …

Deregulation of protein post-translational modifications is intensively involved in the etiology
of diseases, including degenerative diseases, inflammatory injuries, and cancers …