Convergent microstructural brain changes across genetic models of autism spectrum disorder—A pilot study
PA Rowley, J Guerrero-Gonzalez, AL Alexander… - Psychiatry Research …, 2019 - Elsevier
Autism spectrum disorder (ASD) is a complex and genetically heterogeneous
neuropsychiatric disease affecting as many as 1 in 68 children. Large scale genetic …
neuropsychiatric disease affecting as many as 1 in 68 children. Large scale genetic …
Glial-mediated dysregulation of neurodevelopment in Fragile X Syndrome.
M Napier, K Reynolds, AL Scott - International Review of …, 2023 - europepmc.org
Astrocytes are highly involved in a multitude of developmental processes that are known to
be dysregulated in Fragile X Syndrome. Here, we examine these processes individually and …
be dysregulated in Fragile X Syndrome. Here, we examine these processes individually and …
Cortical excitation: inhibition imbalance causes network-specific functional hypoconnectivity: a DREADD-fMRI study
Resting-state fMRI (rsfMRI) is a widespread method utilized for estimating brain-wide
functional connectivity (FC) in health and disease. However, the cellular underpinnings of …
functional connectivity (FC) in health and disease. However, the cellular underpinnings of …
Reduced axonal caliber and structural changes in a rat model of Fragile X syndrome with a deletion of a K-Homology domain of Fmr1
CEM Golden, Y Yee, VX Wang… - Translational …, 2020 - nature.com
Fragile X syndrome (FXS) is a neurodevelopmental disorder that is caused by mutations in
the FMR1 gene. Neuroanatomical alterations have been reported in both male and female …
the FMR1 gene. Neuroanatomical alterations have been reported in both male and female …
Convergent brain microstructure across multiple genetic models of schizophrenia and autism spectrum disorder: a feasibility study
BR Barnett, CP Casey, M Torres-Velázquez… - Magnetic resonance …, 2020 - Elsevier
Neuroimaging studies of psychiatric illness have revealed a broad spectrum of structural
and functional perturbations that have been attributed in part to the complex genetic …
and functional perturbations that have been attributed in part to the complex genetic …
Tbr1 autism mouse model displays altered structural and functional amygdalar connectivity and abnormal whole-brain synchronization
Autism spectrum disorders (ASD) are considered neural dysconnectivity syndromes. To
better understand ASD and uncover potential treatments, it is imperative to know and dissect …
better understand ASD and uncover potential treatments, it is imperative to know and dissect …
Preclinical neuroimaging of gene–environment interactions in psychiatric disease
SY Yi, BR Barnett, JPJ Yu - The British Journal of Radiology, 2019 - academic.oup.com
Psychiatric disease is one of the leading causes of disability worldwide. Despite the global
burden and need for accurate diagnosis and treatment of mental illness, psychiatric …
burden and need for accurate diagnosis and treatment of mental illness, psychiatric …
Age-and Sex-Specific Deterioration on Bone and Osteocyte Lacuno-Canalicular Network in a Mouse Model of Premature Aging
R Mueller, D Yilmaz, FC Marques, L Gregorio… - 2024 - researchsquare.com
Age-related osteoporosis poses a significant challenge in musculoskeletal health; a
condition characterized by reduced bone density and increased fracture susceptibility in …
condition characterized by reduced bone density and increased fracture susceptibility in …
Cyfip1 haploinsufficiency is associated with white matter changes, myelin thinning, reduction of mature oligodendrocytes and behavioural inflexibility
The biological basis of the increased risk for psychiatric disorders due to the pathogenic
15q11. 2 copy number deletion is unknown. Previous work has shown disturbances in white …
15q11. 2 copy number deletion is unknown. Previous work has shown disturbances in white …
Dichotomous Intrinsic Properties of Adult Accumbens Medium Spiny Neurons Vanish in the Fragile X Mouse Model of Autism
G Giua, O Lassalle, L Makrini-Maleville, E Valjent… - bioRxiv, 2022 - biorxiv.org
Fragile X syndrome (FXS), the most common cause of autism and inherited intellectual
disability, is caused by the mutation of a single gene, fmr1, which encodes the Fragile X …
disability, is caused by the mutation of a single gene, fmr1, which encodes the Fragile X …