Chemokines are a class of small chemotactic molecules with cytokine-like functions, which
are well known to orchestrate inflammatory responses within different organs. Overall, more …

Current treatment of HIV/AIDS consists of a combination of three to five agents targeting
different viral proteins, ie the reverse transcriptase, protease, integrase and envelope, and …

Aims Patients with chronic kidney disease (CKD) pose a worldwide growing burden to
health care systems due to accelerated atherosclerosis and subsequent high cardiovascular …

Mesial temporal lobe epilepsy (mTLE) is a chronic and often treatment-refractory brain
disorder characterized by recurrent seizures originating from the hippocampus. The …

Despite the availability of currently approved antiviral drugs, infections with human
cytomegalovirus (HCMV) still cause clinically challenging, sometimes life-threatening …

Importance of the field: Psoriasis is a common, chronic autoimmune disease of the skin.
Despite a number of effective treatments, new therapies are needed with enhanced efficacy …

Tremendous insight into the molecular and genetic pathogenesis of cerebral cavernous
malformations (CCMs) has been gained over the past 2 decades. This includes the …

The interaction between the human immunodeficiency virus (HIV) integrase (IN) and its
cellular cofactor lens epithelium-derived growth factor (LEDGF/p75) is crucial for HIV …

In order to enter and infect human cells HIV must bind to CD4 in addition to either the
CXCR4 or the CCR5 chemokine receptor. AMD11070 was the first orally available small …

To infect host cells, most enveloped viruses must insert a hydrophobic fusion peptide into
the host cell membrane. Thus, fusion peptides may be valuable targets for developing drugs …