Despite the strong conservation of proximal 5′-flanking DNA sequences, cell transfection
and transgenic animal studies have failed to provide a unifying hypothesis to explain the …

Prorenin is expressed in certain extrarenal tissues, but normally only the kidneys process
prorenin to renin and secrete renin into the circulation. Although transgenic animal lines …

Renin, an aspartyl protease that catalyzes the rate-limiting step in the renin-angiotensin
system (RAS), is proteolytically activated by a second protease [referred to as the prorenin …

To create physiological models of the human renin-angiotensin system in transgenic
animals, the component genes should be expressed in the correct tissues and cells and …

Provides detailed discussions of the most recent developments in gene mapping and
manipulation to improve the diagnosis, detection, prevention, and treatment of various …

Cortical expression of the human angiotensinogen gene in the kidney of transgenic mice.
We have previously generated “Tsukuba hypertensive mice” with elevated blood pressure …

The generation of genetically modified animals by transgenic technology is an increasingly
important tool in the field of hypertension. Transgenesis affords the opportunity to analyze …

SIR,-We chose nocturnal monitoring because we expected more episodes of hypoxaemia at
night. We chose to monitor the patients 2-6 days after acute myocardial infarction (AMI) and …