Background The findings of randomised controlled trials (RCT), observational studies, and
meta-analyses vary regarding the effectiveness of prolonged β-lactam infusion. We aimed to …

Infections in critically ill patients are associated with persistently poor clinical outcomes.
These patients have severely altered and variable antibiotic pharmacokinetics and are …

Antimicrobials are among the most important and commonly prescribed drugs in the
management of critically ill patients and beta-lactams are the most common antibiotic class …

Introduction Several reports have shown marked heterogeneity of antibiotic
pharmacokinetics (PK) in patients admitted to ICUs, which might potentially affect outcomes …

The alarming increase of resistance against multiple currently available antibiotics is leading
to a rapid lose of treatment options against infectious diseases. Since the antibiotic …

Introduction Altered pharmacokinetics (PK) in critically ill patients can result in insufficient
serum β-lactam concentrations when standard dosages are administered. Previous studies …

We sought to study whether the better pharmacokinetic and pharmacodynamic (PK/PD)
properties of carbapenems and piperacillin/tazobactam, when the duration of infusion is …

Purpose There is variability in the pharmacokinetics (PK) of antibiotics (AB) in critically ill
patients. Therapeutic drug monitoring (TDM) could overcome this variability and increase PK …

Introduction Sepsis is responsible for important alterations in the pharmacokinetics of
antibiotics. Continuous renal replacement therapy (CRRT), which is commonly used in …

Objectives We utilized the database of the Defining Antibiotic Levels in Intensive care unit
patients (DALI) study to statistically compare the pharmacokinetic/pharmacodynamic and …