Although hormonal regulation of ovarian follicle development has been extensively
investigated, most studies concentrate on the development of early antral follicles to the …

BACKGROUND Primary ovarian insufficiency (POI) is characterized by marked
heterogeneity, but with a significant genetic contribution. Identifying exact causative genes …

BACKGROUND Initially identified for their capability to induce heterotopic bone formation,
bone morphogenetic proteins (BMPs) are multifunctional growth factors that belong to the …

Oogenesis is a complex process regulated by a vast number of intra-and extra-ovarian
factors. Oogonia, which originate from primordial germ cells, proliferate by mitosis and form …

Understanding the physiology underlying the complex dialog between the oocyte and its
surrounding somatic cells within the ovarian follicle has been crucial in defining optimal …

The TGF-β (transforming growth factor-β) system signals via protein kinase receptors and
Smad mediators to regulate a plethora of biological processes, including morphogenesis …

Primary ovarian insufficiency (POI) is characterized by a loss of ovarian function before the
age of 40 and account for one major cause of female infertility. POI relevance is continuously …

BACKGROUND A large number of studies have contributed to understanding the general
mechanisms driving ovarian folliculogenesis in humans and show a complex endocrine …

Background The process of follicle development is tightly regulated by pituitary
gonadotropins (follicle‐stimulating hormone [FSH] and luteinizing hormone [LH]) and …

Growth and differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) are
oocyte-secreted factors with a leading role in the control of ovarian function in female …