Lysine acetylation is a widespread and versatile protein post-translational modification.
Lysine acetyltransferases and lysine deacetylases catalyse the addition or removal …

Microtubules are core components of the eukaryotic cytoskeleton with essential roles in cell
division, shaping, motility and intracellular transport. Despite their functional heterogeneity …

It is well established that maternal age is associated with a rapid decline in the production of
healthy and high-quality oocytes resulting in reduced fertility in women older than 35 years …

Microtubules are non-covalent mesoscale polymers central to the eukaryotic cytoskeleton.
Microtubule structure, dynamics, and mechanics are modulated by a cell's choice of tubulin …

Neurons are markedly compartmentalized, which makes them reliant on axonal transport to
maintain their health. Axonal transport is important for anterograde delivery of newly …

Microtubules are essential dynamic polymers composed of α/β-tubulin heterodimers. They
support intracellular trafficking, cell division, cellular motility, and other essential cellular …

Microtubule (MT)–associated protein 7 (MAP7) is a required cofactor for kinesin-1–driven
transport of intracellular cargoes. Using cryo–electron microscopy and single–molecule …

Abstract Sirtuin 2 (SIRT2) is an NAD+-dependent deacetylase that was under studied
compared to other sirtuin family members. SIRT2 is the only sirtuin protein which is …

The axoneme of motile cilia is the largest macromolecular machine of eukaryotic cells. In
humans, impaired axoneme function causes a range of ciliopathies. Axoneme assembly …

Tubulin posttranslational modifications have been predicted to control cytoskeletal functions
by coordinating the molecular interactions between microtubules and their associating …