* To whom correspondence should be addressed Abbreviations: Cer, ceramide (N-
acylsphingoid); GlcCer, Glc# l~ 1Cer; LacCer, Gal# l~ 4Glc# l--, ICer; Gg3Cer, GalNAcB1 …

RNA interference represents a novel therapeutic approach to modulate several
neurodegenerative disease-related genes. However, exogenous delivery of siRNA restricts …

In recent years, a huge interest in sphingolipid-and cholesterol-enriched membrane
domains has risen, after their involvement in fundamental membrane-associated events …

GM1 is a crucial component of neuronal membrane residing both in the soma and nerve
terminals. As reported in Parkinson's disease patients, the reduction of GM1 determines the …

Glycosphingolipids are ubiquitous components of animal cell membranes. They are
constituted by the basic structure of ceramide with its hydroxyl group linked to single …

Sialic acids are essential constituents of many glycoproteins, glycopeptides and glycolipids.
This widespread occurrence in glycoconjugates of different origin indicates that a variety of …

Gangliosides are sialic acid containing glycosphingolipids, which are abundant in
mammalian brain tissue. Several fatal human diseases are caused by defects in glycolipid …

Filopodia are 5-10 μm long processes that elongate by actin polymerization, and promote
axon growth and guidance by exerting mechanical tension and by molecular signaling …

Protein aggregation is a ubiquitous phenomenon significant to all aspects of science.
Notably, the formation of protein aggregates is frequently encountered in biochemical …

Lipid rafts are cholesterol‐enriched microdomains in plasma membranes. The functional
activity of many membrane proteins, including death and growth factor receptors, depends …