Research progress of targeting NLRP3 inflammasome in peripheral nerve injury and pain

W Li, J Liang, S Li, L Wang, S Xu, S Jiang… - International …, 2022 - Elsevier
Nerve injury and nerve pain are common diseases caused by neuroinflammation.
Numerous studies have shown that the activation of NLRP3 (nod-like receptor family, pyrin …

Role of lipopolysaccharide, derived from various bacterial species, in pulpitis—a systematic review

A Brodzikowska, M Ciechanowska, M Kopka… - Biomolecules, 2022 - mdpi.com
Lipopolysaccharide (LPS) is widely used for induction of inflammation in various human
tissues, including dental pulp. The purpose of this study was to summarize current medical …

Combination of resolvin E1 and lipoxin A4 promotes the resolution of pulpitis by inhibiting NF‐κB activation through upregulating sirtuin 7 in dental pulp fibroblasts

X Liu, C Wang, L Pang, L Pan, Q Zhang - Cell proliferation, 2022 - Wiley Online Library
Objectives To determine whether the combination of resolvin E1 (RvE1) and lipoxin A4
(LXA4) could promote resolution of pulpitis and to investigate the mechanism. Materials and …

Identification of key genes and pathways associated with oxidative stress in periodontitis

Z Zhang, Y Zheng, X Bian, M Wang… - Oxidative Medicine …, 2022 - Wiley Online Library
Background and Objective. Oxidative stress has been associated with the progression of
periodontitis. However, oxidative stress‐related genes (OS‐genes) have not been used as …

The CXCL12-CXCR4-NLRP3 axis promotes Schwann cell pyroptosis and sciatic nerve demyelination in rats

W Li, J Liang, S Li, S Jiang, M Song, S Xu… - Clinical and …, 2023 - academic.oup.com
Studies have shown that the activation of the NOD-like receptor protein 3 (NLRP3)
inflammasome is detrimental to the functional recovery of the sciatic nerve, but the regulatory …

Network pharmacology combined with GEO database identifying the mechanisms and molecular targets of Polygoni Cuspidati Rhizoma on Peri-implants

C Shan, X Ji, Z Wu, J Zhao - Scientific Reports, 2022 - nature.com
Peri-implants is a chronic disease leads to the bone resorption and loss of implants.
Polygoni Cuspidati Rhizoma (PCRER), a traditional Chinese herbal has been used to treat …

[HTML][HTML] Autophagy induced by hypoxia in pulpitis is mediated by HIF-1α/BNIP3

X Wang, Z Wu, Y Zhang, B Lian, L Ma, J Zhao - Archives of Oral Biology, 2024 - Elsevier
Objective Hypoxia-inducible factor-1α (HIF-1α) and its downstream factor, 19 kDa BCL-2
interacting protein 3 (BNIP3), promote cellular autophagy under hypoxic conditions …

Autoimmune Disease-Related Hub Genes are Potential Biomarkers and Associated with Immune Microenvironment in Endometriosis

YT Yang, XY Jiang, HL Xu, G Chen… - … Journal of General …, 2023 - Taylor & Francis
Background Endometriosis, a common gynecological condition, can cause symptoms such
as dysmenorrhea, infertility, and abnormal bleeding, which can negatively affect a woman's …

Guanylate‐binding protein 5‐mediated cell‐autonomous immunity suppresses inflammation in dental pulpitis: An in vitro study

M Huang, C Zhan, B Yang, Y Lu… - International …, 2024 - Wiley Online Library
Aim Guanylate‐binding protein 5 (GBP5) is an interferon (IFN)‐inducible GTPase that plays
a crucial role in the cell‐autonomous immune response against microbial infections. In this …

The role of NF-kappaB in the inflammatory processes related to dental caries, pulpitis, apical periodontitis, and periodontitis–a narrative review

Z Chen, G Lang, X Xu, X Liang, Y Han, Y Han - PeerJ, 2024 - peerj.com
Tooth-related inflammatory disorders, including caries, pulpitis, apical periodontitis (AP), and
periodontitis (PD), are primarily caused by resident oral microorganisms. Although these …