Pathogenesis of preterm birth: bidirectional inflammation in mother and fetus

ES Green, PC Arck - Seminars in immunopathology, 2020 - Springer
Abstract Preterm birth (PTB) complicates 5–18% of pregnancies globally and is a leading
cause of maternal and fetal morbidity and mortality. Most PTB is spontaneous and idiopathic …

Insight into TLR4-mediated immunomodulation in normal pregnancy and related disorders

P Firmal, VK Shah, S Chattopadhyay - Frontiers in immunology, 2020 - frontiersin.org
Unlike organ transplants where an immunosuppressive environment is required, a
successful pregnancy involves an extremely robust, dynamic, and responsive maternal …

Deciphering the endometrial niche of human thin endometrium at single-cell resolution

H Lv, G Zhao, P Jiang, H Wang… - Proceedings of the …, 2022 - National Acad Sciences
Thin endometrium has been widely recognized as a critical cause of infertility, recurrent
pregnancy loss, and placental abnormalities; however, access to effective treatment is a …

Regulatory T cells play a role in a subset of idiopathic preterm labor/birth and adverse neonatal outcomes

N Gomez-Lopez, M Arenas-Hernandez, R Romero… - Cell reports, 2020 - cell.com
Regulatory T cells (Tregs) have been exhaustively investigated during early pregnancy;
however, their role later in gestation is poorly understood. Herein, we report that functional …

Single‐cell transcriptome analysis reveals defective decidua stromal niche attributes to recurrent spontaneous abortion

L Du, W Deng, S Zeng, P Xu, L Huang, Y Liang… - Cell …, 2021 - Wiley Online Library
Objectives Successful pregnancy involves the homeostasis between maternal decidua and
fetoplacental units, whose disruption contributes to compromised pregnancy outcomes …

Spontaneous preterm birth: Involvement of multiple feto-maternal tissues and organ systems, differing mechanisms, and pathways

MS Vidal Jr, RCV Lintao, MEL Severino… - Frontiers in …, 2022 - frontiersin.org
Survivors of preterm birth struggle with multitudes of disabilities due to improper in utero
programming of various tissues and organ systems contributing to adult-onset diseases at a …

Perinatal infection, inflammation, preterm birth, and brain injury: A review with proposals for future investigations

JD Reiss, LS Peterson, SN Nesamoney, AL Chang… - Experimental …, 2022 - Elsevier
Preterm newborns are exposed to several risk factors for developing brain injury. Clinical
studies have suggested that the presence of intrauterine infection is a consistent risk factor …

[HTML][HTML] Glycerol monolaurate improves intestinal morphology and antioxidant status by suppressing inflammatory responses and nuclear factor kappa-B signaling in …

L Kong, Y Cai, X Pan, C Xiao, Z Song - Animal Nutrition, 2023 - Elsevier
Medium-chain fatty acids and their derivatives are natural ingredients that support
immunological functions in animals. The effects of glycerol monolaurate (GML) on intestinal …

Intrauterine infusion of human platelet-rich plasma improves endometrial regeneration and pregnancy outcomes in a murine model of Asherman's syndrome

JH Kim, M Park, JY Paek, WS Lee, H Song… - Frontiers in …, 2020 - frontiersin.org
Asherman's syndrome (AS) is characterized by intrauterine adhesion or fibrosis resulting
from damage to the endometrium, often leading to amenorrhea, infertility, or recurrent …

Primary decidual zone formation requires Scribble for pregnancy success in mice

J Yuan, S Aikawa, W Deng, A Bartos, G Walz… - Nature …, 2019 - nature.com
Scribble (Scrib) is a scaffold protein with multifunctional roles in PCP, tight junction and
Hippo signaling. This study shows that Scrib is expressed in stromal cells around the …