[HTML][HTML] Reducing the metabolic burden of rRNA synthesis promotes healthy longevity in Caenorhabditis elegans
S Sharifi, P Chaudhari, A Martirosyan… - Nature …, 2024 - nature.com
Ribosome biogenesis is initiated by RNA polymerase I (Pol I)-mediated synthesis of pre-
ribosomal RNA (pre-rRNA). Pol I activity was previously linked to longevity, but the …
ribosomal RNA (pre-rRNA). Pol I activity was previously linked to longevity, but the …
Dioscin Activates Endoplasmic Reticulum Unfolded Protein Response for Defense Against Pathogenic Bacteria in Caenorhabditis elegans via IRE-1/XBP-1 Pathway
Y Xiao, F Liu, Q Wu, X Zhu, C Yu… - The Journal of …, 2024 - academic.oup.com
The unfolded protein response (UPR) is an evolutionarily conserved pathway that senses
and responds to the accumulation of misfolded proteins in the endoplasmic reticulum (ER) …
and responds to the accumulation of misfolded proteins in the endoplasmic reticulum (ER) …
Cynaroside extends lifespan and improves the neurondegeneration diseases via insulin/IGF-1 signaling pathway in Caenorhabditis elegans
Y Xiao, Y Zhang, L Li, N Jiang, C Yu, S Li, X Zhu… - Archives of Gerontology …, 2024 - Elsevier
The evolutionarily conserved insulin/IGF-1 signaling pathway plays a central role in aging
and aging related diseases such as neurodegeneration diseases. Inhibition of insulin/IGF-1 …
and aging related diseases such as neurodegeneration diseases. Inhibition of insulin/IGF-1 …
[HTML][HTML] Dioscin inhibiting EGFR-mediated Survivin expression promotes apoptosis in oral squamous cell carcinoma cells
M Li, Q Zhao, J Liao, X Wang, L Liu, X Zhang… - Journal of …, 2023 - ncbi.nlm.nih.gov
Overexpression of survivin plays a crucial role in tumorigenesis and correlates with poor
prognosis in human malignancies, including oral squamous cell carcinoma (OSCC). Thus …
prognosis in human malignancies, including oral squamous cell carcinoma (OSCC). Thus …