Given that the PI3K/AKT pathway has manifested its compelling influence on multiple
cellular process, we further review the roles of hyperactivation of PI3K/AKT pathway in …

The medical history of cancer began millennia ago. Historical findings of patients with
cancer date back to ancient Egyptian and Greek civilizations, where this disease was …

Compared with traditional de novo drug discovery, drug repurposing has become an
attractive drug discovery strategy due to its low-cost and high efficiency. Through a …

Melanoma develops from malignant transformations of the pigment-producing melanocytes.
If located in the basal layer of the skin epidermis, melanoma is referred to as cutaneous …

Glioblastoma multiforme is the most aggressive malignant tumor of the central nervous
system. Due to the absence of effective pharmacological and surgical treatments, the …

The BRAF inhibitors vemurafenib, dabrafenib and encorafenib are used in the treatment of
patients with BRAF-mutant melanoma. They selectively target BRAF kinase and thus …

Cutaneous melanoma (CM) is a malignant tumor formed from pigment-producing cells
called melanocytes. It is one of the most aggressive and fatal forms of skin malignancy. In …

In a relatively short period of time, treatment strategies for metastatic melanoma have
radically changed leading to an unprecedented improvement in patient survival. In this …

Uveal melanoma (UM) represents the most prominent primary eye cancer in adults. With an
incidence of approximately 5 cases per million individuals annually in the United States, UM …

Melanoma is an aggressive malignancy deriving from melanocytes, which is characterized
by high tendency of metastases and mortality rate. Current therapies for melanoma, like …