Genetic studies have yielded important genes contributing to both early-onset and adult-
onset forms of glaucoma. The proteins encoded by the current collection of glaucoma genes …

Neurodevelopmental disorders (NDDs) are clinically and genetically heterogenous; many
such disorders are secondary to perturbation in brain development and/or function. The …

Ion channels are the second largest class of drug targets after G protein-coupled receptors.
In addition to well-recognized ones like voltage-gated Na/K/Ca channels in the heart and …

Background Characterizing large genomic variants is essential to expanding the research
and clinical applications of genome sequencing. While multiple data types and methods are …

TMCO1 (transmembrane and coiled-coil domains 1) is an endoplasmic reticulum (ER)
transmembrane protein that actively prevents Ca2+ stores from overfilling. To characterize …

Transmembrane and coiled-coil domains 1 (TMCO1) is a recently identified Ca2+ leak
channel in the endoplasmic reticulum. TMCO1 dysfunction in humans is associated with …

Ca2+ release from the endoplasmic reticulum (ER) is an essential event in the modulation of
Ca2+ homeostasis, which is coordinated by multiple biological processes, ranging from cell …

Transmembrane of coiled-coil domains 1 (TMCO1) plays an important role in maintaining
homeostasis of calcium (Ca2+) stores in the endoplasmic reticulum (ER). TMCO1-defect …

Purpose.: We examined the role of DNA copy number variants (CNVs) of known glaucoma
genes in relation to primary open angle glaucoma (POAG). Methods.: Our study included …

First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
52630910&utm_source= google_patent&utm_medium= platform_link&utm_campaign …