Understanding and approaching excessive daytime sleepiness

L Pérez-Carbonell, E Mignot, G Leschziner… - The Lancet, 2022 - thelancet.com
Excessive daytime sleepiness (EDS) is a public health issue. However, it remains largely
undervalued, scarcely diagnosed, and poorly supported. Variations in the definition of EDS …

Toward precision medicine: circadian rhythm of blood pressure and chronotherapy for hypertension-2021 NHLBI workshop report

ML Gumz, D Shimbo, M Abdalla, RC Balijepalli… - …, 2023 - Am Heart Assoc
Healthy individuals exhibit blood pressure variation over a 24-hour period with higher blood
pressure during wakefulness and lower blood pressure during sleep. Loss or disruption of …

Circadian immunity from bench to bedside: a practical guide

H Mok, E Ostendorf, A Ganninger… - The Journal of …, 2024 - Am Soc Clin Investig
The immune system is built to counteract unpredictable threats, yet it relies on predictable
cycles of activity to function properly. Daily rhythms in immune function are an expanding …

Self-supervised learning of accelerometer data provides new insights for sleep and its association with mortality

H Yuan, T Plekhanova, R Walmsley, AC Reynolds… - NPJ digital …, 2024 - nature.com
Sleep is essential to life. Accurate measurement and classification of sleep/wake and sleep
stages is important in clinical studies for sleep disorder diagnoses and in the interpretation …

Depression and lifestyle: focusing on nutrition, exercise, and their possible relevance to molecular mechanisms

H Kunugi - Psychiatry and Clinical Neurosciences, 2023 - Wiley Online Library
Accumulating evidence has suggested the important role of lifestyle factors in depressive
disorder. This paper aimed to introduce and outline recent research on epidemiological and …

Effects of exercise on circadian rhythms in humans

B Shen, C Ma, G Wu, H Liu, L Chen… - Frontiers in …, 2023 - frontiersin.org
The biological clock system is an intrinsic timekeeping device that integrates internal
physiology and external cues. Maintaining a healthy biological clock system is crucial for life …

The mammalian circadian time-keeping system

AP Patton, MH Hastings - Journal of Huntington's disease, 2023 - content.iospress.com
Our physiology and behavior follow precise daily programs that adapt us to the alternating
opportunities and challenges of day and night. Under experimental isolation, these rhythms …

The devastating effects of sleep deprivation on memory: lessons from rodent models

P Chen, W Ban, W Wang, Y You, Z Yang - Clocks & Sleep, 2023 - mdpi.com
In this narrative review article, we discuss the role of sleep deprivation (SD) in memory
processing in rodent models. Numerous studies have examined the effects of SD on …

Sleep function: an evolutionary perspective

JM Siegel - The Lancet Neurology, 2022 - thelancet.com
Prospective epidemiological studies in industrial societies indicate that 7 h of sleep per night
in people aged 18 years or older is optimum, with higher and lower amounts of sleep …

The melatonin receptor 1B gene links circadian rhythms and type 2 diabetes mellitus: An evolutionary story

H Zhu, Z Zhao, H Liu, J Cai, Q Lu, L Ji, J Xu - Annals of Medicine, 2023 - Taylor & Francis
Disturbed circadian rhythms have been a risk factor for type 2 diabetes mellitus (T2DM).
Melatonin is the major chronobiotic hormone regulating both circadian rhythm and glucose …