Alcohol addiction is a leading risk factor for personal death and disability. In 2016, alcohol
use caused 2.2% of female deaths and 6.8% of male deaths, and disability-adjusted life …

The dramatic increase in opioid misuse, opioid use disorder (OUD), and opioid‐related
overdose deaths in the United States has led to public outcry, policy statements, and funding …

Heavy drinking and alcohol use disorder are major public health problems. Practitioners not
specialising in alcohol treatment are often unaware of the guidelines for preventing …

Pathological substance use disorders represent a major public health crisis with limited
effective treatment options. While much work has been done to understand the neuronal …

Alcohol use disorder (AUD) encompasses the dysregulation of multiple brain circuits
involved in executive function leading to excessive consumption of alcohol, despite negative …

Drug treatments available for the management of substance use disorders (SUD) present
multiple limitations in efficacy, lack of approved treatments or alarming relapse rates. These …

Drug abuse is a major global health and economic problem. However, there are no
pharmacological treatments to effectively reduce the compulsive use of most drugs of abuse …

Pathologic alcohol use affects more than 2 billion people and accounts for nearly 6% of all
deaths worldwide. There are three medications approved for the treatment of alcohol use …

Substance use disorders are global health problems with few effective treatment options.
Unfortunately, most potential pharmacological treatments are hindered by abuse potential of …

Compounds known to be successful in the treatment of alcohol use disorder include the
aversive agent, Disulfiram, the glutamatergic NMDA receptor antagonist, Acamprosate, and …