Molecular mechanisms of environmental exposures and human disease
A substantial proportion of disease risk for common complex disorders is attributable to
environmental exposures and pollutants. An appreciation of how environmental pollutants …
environmental exposures and pollutants. An appreciation of how environmental pollutants …
[HTML][HTML] Methyltransferase-like proteins in cancer biology and potential therapeutic targeting
YN Qi, Z Liu, LL Hong, P Li, ZQ Ling - Journal of Hematology & Oncology, 2023 - Springer
RNA modification has recently become a significant process of gene regulation, and the
methyltransferase-like (METTL) family of proteins plays a critical role in RNA modification …
methyltransferase-like (METTL) family of proteins plays a critical role in RNA modification …
[HTML][HTML] Regulatory mechanisms and therapeutic implications of insulin-like growth factor 2 mRNA-binding proteins, the emerging crucial m6A regulators of tumors
H Zhou, Q Sun, M Feng, Z Gao, S Jia, L Cao, X Yu… - Theranostics, 2023 - ncbi.nlm.nih.gov
Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) serve essential biological
functions as post-transcriptional performers, participating in the acquisition or maintenance …
functions as post-transcriptional performers, participating in the acquisition or maintenance …
Site-specific Atg13 methylation-mediated autophagy regulates epithelial inflammation in PM2. 5-induced pulmonary fibrosis
J Ning, Z Pei, M Wang, H Hu, M Chen, Q Liu… - Journal of hazardous …, 2023 - Elsevier
Abstract Fine particulate matters (PM2. 5) increased the risk of pulmonary fibrosis. However,
the regulatory mechanisms of lung epithelium in pulmonary fibrosis remained elusive. Here …
the regulatory mechanisms of lung epithelium in pulmonary fibrosis remained elusive. Here …
Cigarette smoking, by accelerating the cell cycle, promotes the progression of non-small cell lung cancer through an HIF-1α-METTL3-m6A/CDK2AP2 axis
Y Yang, C Cheng, B He, X Du, J Liu, H Xia… - Journal of hazardous …, 2023 - Elsevier
Cigarette smoking killed about 8 million people every year and promoted non-small cell lung
cancer (NSCLC). We investigated the molecular mechanism of smoking-promoted NSCLC …
cancer (NSCLC). We investigated the molecular mechanism of smoking-promoted NSCLC …
[HTML][HTML] YTHDF1 promotes bladder cancer cell proliferation via the METTL3/YTHDF1–RPN2–PI3K/AKT/mTOR axis
J Zhu, H Tong, Y Sun, T Li, G Yang, W He - International Journal of …, 2023 - mdpi.com
N6-methyladenosine (m6A) is the most common mRNA modification and it plays a critical
role in tumor progression, prognoses and therapeutic response. In recent years, more and …
role in tumor progression, prognoses and therapeutic response. In recent years, more and …
WTAP activates MAPK signaling through m6A methylation in VEGFA mRNA‐mediated by YTHDC1 to promote colorectal cancer development
M Ye, J Chen, P Yu, C Hu, B Wang, J Bao… - The FASEB …, 2023 - Wiley Online Library
N6‐methyladenosine modification, especially Wilms tumor 1‐associated protein (WTAP), is
reportedly associated with a variety of cancers, including colorectal cancer (CRC) …
reportedly associated with a variety of cancers, including colorectal cancer (CRC) …
Interaction between N6-methyladenosine (m6A) modification and environmental chemical-induced diseases in various organ systems
X Zhu, H Fu, J Sun, Q Xu - Chemico-Biological Interactions, 2023 - Elsevier
A wide variety of chemicals are ubiquitous in the environment and thus exposure to these
environmental chemicals poses a serious threat to public health. Particularly, environmental …
environmental chemicals poses a serious threat to public health. Particularly, environmental …
[HTML][HTML] METTL16 suppressed the proliferation and cisplatin-chemoresistance of bladder cancer by degrading PMEPA1 mRNA in a m6A manner through autophagy …
H Yu, J Zhuang, Z Zhou, Q Song, J Lv… - … Journal of Biological …, 2024 - ncbi.nlm.nih.gov
Abstract N6-methyladenosine (m6A) is important in the physiological processes of many
species. Methyltransferase-like 16 (METTL16) is a novel discovered m6A methylase …
species. Methyltransferase-like 16 (METTL16) is a novel discovered m6A methylase …
The role of N6-methyladenosine methylation in PAHs-induced cancers
Y Wei, X Guo, L Li, W Xue, L Wang, C Chen… - … Science and Pollution …, 2023 - Springer
Polycyclic aromatic hydrocarbons (PAHs), which are a wide range of environmental
toxicants, may act on humans through inhalation, ingestion, and skin contact, resulting in a …
toxicants, may act on humans through inhalation, ingestion, and skin contact, resulting in a …