Osteoarthritis: pathogenic signaling pathways and therapeutic targets
Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …
more than 500 million population worldwide. OA was believed to be caused by the wearing …
Synovial inflammation in osteoarthritis progression
E Sanchez-Lopez, R Coras, A Torres… - Nature Reviews …, 2022 - nature.com
Osteoarthritis (OA) is a progressive degenerative disease resulting in joint deterioration.
Synovial inflammation is present in the OA joint and has been associated with radiographic …
Synovial inflammation is present in the OA joint and has been associated with radiographic …
Prevalence trends of site‐specific osteoarthritis from 1990 to 2019: findings from the global burden of disease study 2019
H Long, Q Liu, H Yin, K Wang, N Diao… - Arthritis & …, 2022 - Wiley Online Library
Objective To estimate systematic and anatomic site–specific age‐standardized prevalence
rates (ASRs) and analyze the secular trends of osteoarthritis (OA) at global, regional, and …
rates (ASRs) and analyze the secular trends of osteoarthritis (OA) at global, regional, and …
Global, regional prevalence, incidence and risk factors of knee osteoarthritis in population-based studies
A Cui, H Li, D Wang, J Zhong, Y Chen, H Lu - EClinicalMedicine, 2020 - thelancet.com
Background Knee osteoarthritis (OA) is a major cause of disability in the elderly, however,
there are few studies to estimate the global prevalence, incidence, and risk factors of knee …
there are few studies to estimate the global prevalence, incidence, and risk factors of knee …
Osteoarthritis: pathology, diagnosis, and treatment options
B Abramoff, FE Caldera - Medical Clinics, 2020 - medical.theclinics.com
Osteoarthritis (OA) is endemic throughout the world. An estimated 30.8 million adults in the
United States and 300 million individuals worldwide are living with OA. 1, 2 It is the leading …
United States and 300 million individuals worldwide are living with OA. 1, 2 It is the leading …
Global, regional and national burden of osteoarthritis 1990-2017: a systematic analysis of the Global Burden of Disease Study 2017
Objectives To report the level and trends of prevalence, incidence and years lived with
disability (YLDs) for osteoarthritis (OA) in 195 countries and territories from 1990 to 2017 by …
disability (YLDs) for osteoarthritis (OA) in 195 countries and territories from 1990 to 2017 by …
Stem cell–homing hydrogel-based miR-29b-5p delivery promotes cartilage regeneration by suppressing senescence in an osteoarthritis rat model
J Zhu, S Yang, Y Qi, Z Gong, H Zhang, K Liang… - Science …, 2022 - science.org
Osteoarthritis (OA) is a common joint disease characterized by progressive loss of cartilage
and reduction in lubricating synovial fluid, which lacks effective treatments currently. Here …
and reduction in lubricating synovial fluid, which lacks effective treatments currently. Here …
Age-related matrix stiffening epigenetically regulates α-Klotho expression and compromises chondrocyte integrity
Extracellular matrix stiffening is a quintessential feature of cartilage aging, a leading cause
of knee osteoarthritis. Yet, the downstream molecular and cellular consequences of age …
of knee osteoarthritis. Yet, the downstream molecular and cellular consequences of age …
Incidence and prevalence of patellofemoral pain: a systematic review and meta-analysis
Background Patellofemoral pain is considered one of the most common forms of knee pain,
affecting adults, adolescents, and physically active populations. Inconsistencies in reported …
affecting adults, adolescents, and physically active populations. Inconsistencies in reported …
Ageing and the pathogenesis of osteoarthritis
RF Loeser, JA Collins, BO Diekman - Nature Reviews Rheumatology, 2016 - nature.com
Ageing-associated changes that affect articular tissues promote the development of
osteoarthritis (OA). Although ageing and OA are closely linked, they are independent …
osteoarthritis (OA). Although ageing and OA are closely linked, they are independent …