[HTML][HTML] Defining memory CD8 T cell
MD Martin, VP Badovinac - Frontiers in immunology, 2018 - frontiersin.org
CD8 T cells comprising the memory pool display considerable heterogeneity, with individual
cells differing in phenotype and function. This review will focus on our current understanding …
cells differing in phenotype and function. This review will focus on our current understanding …
Memory T cells: strategies for optimizing tumor immunotherapy
Q Liu, Z Sun, L Chen - Protein & cell, 2020 - academic.oup.com
Several studies have demonstrated that memory T cells including stem cell memory (Tscm)
T cells and central memory (Tcm) T cells show superior persistence and antitumor immunity …
T cells and central memory (Tcm) T cells show superior persistence and antitumor immunity …
Emerging targets in cancer immunotherapy
S Burugu, AR Dancsok, TO Nielsen - Seminars in cancer biology, 2018 - Elsevier
The first generation of immune checkpoint inhibitors (anti-CTLA-4 and anti-PD-1/PD-L1)
targeted natural immune homeostasis pathways, co-opted by cancers, to drive anti-tumor …
targeted natural immune homeostasis pathways, co-opted by cancers, to drive anti-tumor …
Pooled screening of CAR T cells identifies diverse immune signaling domains for next-generation immunotherapies
Chimeric antigen receptors (CARs) repurpose natural signaling components to retarget T
cells to refractory cancers but have shown limited efficacy in persistent, recurrent …
cells to refractory cancers but have shown limited efficacy in persistent, recurrent …
[HTML][HTML] Single-cell genomics unveils critical regulators of Th17 cell pathogenicity
Extensive cellular heterogeneity exists within specific immune-cell subtypes classified as a
single lineage, but its molecular underpinnings are rarely characterized at a genomic scale …
single lineage, but its molecular underpinnings are rarely characterized at a genomic scale …
CD27 costimulation augments the survival and antitumor activity of redirected human T cells in vivo
The costimulatory effects of CD27 on T lymphocyte effector function and memory formation
has been confined to evaluations in mouse models, in vitro human cell culture systems, and …
has been confined to evaluations in mouse models, in vitro human cell culture systems, and …
Timing and tuning of CD27–CD70 interactions: the impact of signal strength in setting the balance between adaptive responses and immunopathology
MA Nolte, RW Van Olffen… - Immunological …, 2009 - Wiley Online Library
After binding its natural ligand cluster of differentiation 70 (CD70), CD27, a tumor necrosis
factor receptor (TNFR)‐associated factor‐binding member of the TNFR family, regulates …
factor receptor (TNFR)‐associated factor‐binding member of the TNFR family, regulates …
Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH17 cells
We used a sensitive method based on tetramers of peptide and major histocompatibility
complex II (pMHCII) to determine whether CD4+ memory T cells resemble the T helper type …
complex II (pMHCII) to determine whether CD4+ memory T cells resemble the T helper type …
Temporal changes in dendritic cell subsets, cross-priming and costimulation via CD70 control CD8+ T cell responses to influenza
A Ballesteros-Tato, B León, FE Lund, TD Randall - Nature immunology, 2010 - nature.com
The question of which dendritic cells (DCs) respond to pulmonary antigens and cross-prime
CD8+ T cells remains controversial. We show here that influenza-specific CD8+ T cell …
CD8+ T cells remains controversial. We show here that influenza-specific CD8+ T cell …
Targeting the T-cell co-stimulatory CD27/CD70 pathway in cancer immunotherapy: rationale and potential
K Van De Ven, J Borst - Immunotherapy, 2015 - Future Medicine
In 2013, cancer immunotherapy was named 'breakthrough of the year'based on the outcome
of clinical trials with blocking antibodies to the T-cell co-inhibitory receptors CTLA-4 and PD …
of clinical trials with blocking antibodies to the T-cell co-inhibitory receptors CTLA-4 and PD …