CD4+ T cells promote CD8+ T cell priming by licensing dendritic cells (DCs) via CD40–
CD154 interactions. However, the initial requirement for CD40 signaling may be replaced by …

Objective—Immune cells play a critical role in atherosclerosis. Costimulatory and
coinhibitory molecules of the tumor necrosis factor receptor and CD28 immunoglobulin …

Highlights•CD27 is a critical link from activated dendritic cells to T cells and NK cells, and
can be constrained by Treg pruning of its ligand, CD70.•CD27 stimulation promotes both NK …

Chronic infection results in continuous formation and exhaustion of effector CD8 T cells and
in failure of memory CD8 T cell development. Expression of CD70 and other molecules that …

Fully functional CD8+ T cell memory is highly dependent upon CD4+ T cell support. CD4+ T
cells play a critical role in inducing the expression of CD70, the ligand for CD27, on dendritic …

Naive T cells require signals from multiple costimulatory receptors to acquire full effector
function and differentiate to long‐lived memory cells. The costimulatory receptor, CD 27, is …

CD8 memory T cells can play a critical role in protection against repeated exposure to
infectious agents such as viruses, yet can also contribute to the immunopathology …

Abstract Chimeric antigen receptor (CAR)--engineered T cells have been defined as 'living
drug'. Adding a co-stimulatory domain (CSD) has enhanced the anti-hematological effects of …

Clinically, xenotransplantation often leads to T-cell-mediated graft rejection.
Immunosuppressive agents including polyclonal regulatory T cells (poly-Tregs) promote …

A single nucleotide polymorphism‐chip analysis of 98 cases of aggressive B‐cell
lymphomas revealed a recurrent deletion at 19p13 in nine of the cases. Six further cases …