Induction of apoptosis represents a promising therapeutic approach to drive tumor cells to
death. However, this poses challenges due to the intricate nature of cancer biology and the …

Receptors belonging to the TNF-receptor (TNF-R) superfamily include important
costimulatory molecules, many of which specifically affect T cell activation. TNF receptor …

Signaling through CD27 plays a role in T cell activation and memory. However, it is currently
unknown how this costimulatory receptor influences CD4+ effector T (Teff) cells in inflamed …

Natural killer (NK) cells are part of the first line defense against tumors, parasites and virus‐
infected cells. Therefore, factors that control NK‐cell numbers and their function are …

Adenoviral vectored vaccines have shown considerable promise but could be improved by
molecular adjuvants. Ligands in the TNF superfamily (TNFSF) are potential adjuvants for …

Abstract Helper-dependent, CD40-independent, CD8+ T cell responses are shown to be
CD70-dependent, demonstrating alternative mechanisms by which CD4+ T cells induce …

Apoptosis plays an essential role in the removal of activated CD8 T cells that are no longer
required during or postinfection. The Bim-dependent intrinsic pathway of apoptosis removes …

The human respiratory tract is an entry point for over 200 known viruses that collectively
contribute to millions of annual deaths worldwide. Consequently, the World Health …

WO2016138488A2 - T cell balance gene expression, compositions of matters and methods of
use thereof - Google Patents WO2016138488A2 - T cell balance gene expression …

Highlights•Targeting TNFRSF receptors during vaccination results in exponentially larger T
cell responses.•PRR-inducted inflammatory cytokines synergize with stimulation of TNFSF …