The factors that determine differentiation of naive CD8 T cells into memory cells are not well
understood. A greater understanding of how memory cells are generated will inform of ways …

Glioblastoma (GBM) is a uniformly lethal cancer with an overall survival of less than 15
months. Aggressive standard of care therapies fail to eradicate these tumors and are non …

For optimal quality, memory CD8 T cells require CD4 T cell help. We have examined
whether CD4 T cells require CD27 to deliver this help, in a model of intranasal OVA protein …

The severe disease associated with seasonal epidemics of influenza A virus (IAV), as well
as pandemic outbreaks, have highlighted the necessity for novel, broadly cross-reactive …

Vė žio imu no lo gi ja–vie na iš po pu lia riau sių na vi kų ty ri mo sri čių. Straips ny je ap žvel
gia ma vė žio imu no lo gi jos, na vi ko su ke lia mos imu nosup re si jos ak tu a lu mo pro ble …

Activation and proliferation of antigen-specific T cells is the hallmark of an anti-viral immune
response. Effector T cells generated during an immune response are heterogeneous in …

Despite the recent successes of using immune modulatory antibodies in cancer patients,
autoimmune pathologies resulting from the activation of self reactive T cells preclude the …

Animal models make an important contribution to the study of infectious diseases, both for
the characteristics of the infection as well as in the development of vaccines and …

Tissue resident memory CD8 (T RM) cells have been identified in multiple peripheral tissues
after local infections, and are considered to be an important component of local immunity …

CD27 interactions with its ligand, CD70, are thought to be necessary for optimal primary and
memory adaptive immune responses to a variety of pathogens. Thus far, all studies …