Pathogenesis of pneumonia and acute lung injury

ME Long, RK Mallampalli, JC Horowitz - Clinical Science, 2022 - portlandpress.com
Pneumonia and its sequelae, acute lung injury, present unique challenges for pulmonary
and critical care healthcare professionals, and these challenges have recently garnered …

[HTML][HTML] Comorbid chronic diseases and acute organ injuries are strongly correlated with disease severity and mortality among COVID-19 patients: a systemic review …

X Wang, X Fang, Z Cai, X Wu, X Gao, J Min, F Wang - Research, 2020 - spj.science.org
The recent outbreak of COVID-19 has been rapidly spreading on a global scale. To date,
there is no specific vaccine against the causative virus, SARS-CoV-2, nor is there an …

Mapping the human genetic architecture of COVID-19

Writing group Writing group leaders Pathak Gita A. 6 … - Nature, 2021 - nature.com
The genetic make-up of an individual contributes to the susceptibility and response to viral
infection. Although environmental, clinical and social factors have a role in the chance of …

Genetic ancestry effects on the response to viral infection are pervasive but cell type specific

HE Randolph, JK Fiege, BK Thielen, CK Mickelson… - Science, 2021 - science.org
Humans differ in their susceptibility to infectious disease, partly owing to variation in the
immune response after infection. We used single-cell RNA sequencing to quantify variation …

Initial whole-genome sequencing and analysis of the host genetic contribution to COVID-19 severity and susceptibility

F Wang, S Huang, R Gao, Y Zhou, C Lai, Z Li, W Xian… - Cell discovery, 2020 - nature.com
The COVID-19 pandemic has accounted for millions of infections and hundreds of thousand
deaths worldwide in a short-time period. The patients demonstrate a great diversity in …

Systematic review and meta-analysis of human genetic variants contributing to COVID-19 susceptibility and severity

K Gupta, G Kaur, T Pathak, I Banerjee - Gene, 2022 - Elsevier
The COVID-19 pandemic has spawned global health crisis of unprecedented magnitude,
claiming millions of lives and pushing healthcare systems in many countries to the brink …

Mapping the human genetic architecture of COVID-19: an update

COVID-19 Host Genetics Initiative, A Ganna - MedRxiv, 2021 - medrxiv.org
Abstract The Coronavirus Disease 2019 (COVID-19) pandemic continues to pose a major
public health threat especially in countries with low vaccination rates. To better understand …

The Interferon-induced transmembrane protein 3 gene (IFITM3) rs12252 C variant is associated with COVID-19

J Gómez, GM Albaiceta, E Cuesta-Llavona… - Cytokine, 2021 - Elsevier
Background and aims The interferon-induced transmembrane proteins play an important
antiviral role by preventing viruses from traversing the cellular lipid bilayer. IFITM3 gene …

Cell-mediated immune responses to COVID-19 infection

A Guihot, E Litvinova, B Autran, P Debré… - Frontiers in …, 2020 - frontiersin.org
An unprecedented outbreak of pneumonia caused by a novel coronavirus (CoV),
subsequently termed COVID-19 by the World Health Organization, emerged in Wuhan City …

Host genetic polymorphisms involved in long-term symptoms of COVID-19

W Udomsinprasert, N Nontawong… - Emerging Microbes & …, 2023 - Taylor & Francis
Host genetic polymorphisms are recognized as a critical determinant of diversity in clinical
symptoms of Coronavirus disease 2019 (COVID-19). Accordingly, this study aimed to …