Parkinson's disease (PD) is a complex, multi-system neurodegenerative disorder. The
second most common neurodegenerative disorder after Alzheimer's disease, it affects …

Dopamine shapes a wide variety of psychomotor functions. This is mainly accomplished by
modulating cortical and thalamic glutamatergic signals impinging upon principal medium …

The formation of mature mRNAs in vertebrates involves the cleavage and polyadenylation of
the pre-mRNA, 10–30 nt downstream of an AAUAAA or AUUAAA signal sequence. The …

We have used gene targeting to examine the role of the Gα subunit, G olf, in olfactory signal
transduction. Mice homozygous for a null mutation in G olf show a striking reduction in the …

The striatum has been involved in complex behaviors such as motor control, learning,
decision-making, reward and aversion. The striatum is mainly composed of medium spiny …

Schild, Detlev, and Diego Restrepo. Transduction Mechanisms in Vertebrate Olfactory
Receptor Cells. Physiol. Rev. 78: 429–466, 1998.—Considerable progress has been made …

The G-protein-mediated signalling system has evolved as one of the most widely used
transmembrane signalling mechanisms in mammalian organisms. All mammalian cells …

SKF-81297 or the psychostimulant cocaine. Moreover, Golfα knockout mice did not display
cocaine-induced c-fos expression in the striatum. Finally, in the absence of Golfα, striatal D1 …

Parkinson disease (PD) is no longer considered a complex motor disorder but rather a
systemic disease with variable nonmotor deficits that may include impaired olfaction …

In the striatum, dopamine D1 and adenosine A2A receptors stimulate the production of
cAMP, which is involved in neuromodulation and long-lasting changes in gene expression …