Angiopoietin 2 (Ang2) was originally shown to be a competitive antagonist for Ang1 of the
receptor tyrosine kinase Tie2 in endothelial cells (ECs). Since then, reports have conflicted …

Primary congenital glaucoma (PCG) is a devastating eye disease and an important cause of
childhood blindness worldwide. In PCG, defects in the anterior chamber aqueous humor …

A productive angiogenic response must couple to the survival machinery of endothelial cells
to preserve the integrity of newly formed vessels. Angiopoietin-1 (Ang-1) is an endothelium …

PURPOSE: To compare the efficacy of fluorescence in situ hybridization (FISH) and
immunohistochemistry (IHC) in detecting the HER-2/neu alteration in human breast cancer …

Venous malformations (VM) are vascular malformations characterized by enlarged and
distorted blood vessel channels. VM grow over time and cause substantial morbidity …

Although tight‐junctions (TJs) at the blood–brain barrier (BBB) are important to prevent non‐
specific entry of compounds into the CNS, molecular mechanisms regulating TJ …

Angiogenesis is required for normal embryonic vascular development and aberrant
angiogenesis contributes to several diseases, including cancer, diabetes and tissue …

This review focuses on the signaling system involving the Angiopoietin1/Tie2 receptor,
which appears to be involved in the secondary stages of blood vessel formation. Although …

Background Biochemical, genetic, and clinical evidence indicates that smooth-muscle
proliferation around small pulmonary vessels is an essential part of the pathogenesis of …

Angiopoietins are ligands of the Tie2 receptor that control angiogenic remodeling in a
context-dependent manner. Tie signaling is involved in multiple steps of the angiogenic …