Tek/Tie‐2 is an endothelial cell (EC)‐specific receptor tyrosine kinase that plays a critical
role in angiogenesis via its regulation by the angiopoietin family of growth factor ligands …

Tie2/Tek is an endothelial cell receptor tyrosine kinase that induces signal transduction
pathways involved in cell migration upon angiopoietin-1 (Ang1) stimulation. To address the …

The orphan receptor tyrosine kinase Tie-1 is expressed in endothelial cells and is essential
for vascular development. Nothing is known about the signaling pathways utilized by this …

The application of surface plasmon resonance biosensors in life sciences and
pharmaceutical research continues to increase. This review provides a comprehensive list of …

During embryogenesis, the formation of primary vascular networks occurs via the processes
of vasculogenesis and angiogenesis. In uveal melanoma, vasculogenic mimicry describes …

Angiopoietins are ligands for endothelial cell-specific Tie-2 receptors. Whereas angiopoietin-
1 (Ang-1) activates these receptors and promotes cell survival, migration, and sprouting, little …

Dok (for downstream of tyrosine kinases) proteins are a newly identified family of docking
molecules that are characterized by the presence of an amino-terminal pleckstrin homology …

Introduction 3. Structure 3.1. Proline-rich region 3.2. GM region 3.2. 1. PH domain 3.2. 2. RA
domain 3.2. 3. BPS/PIR region 3.3. SH2 domain 4. Potential regulatory mechanisms 4.1 …

Growth factor receptor-bound 2 (Grb2) is a ubiquitously expressed adapter protein that
provides a critical link between cell surface growth factor receptors and the Ras signaling …

Grb7 is an adapter-type signaling protein, which is recruited via its SH2 domain to a variety
of receptor tyrosine kinases (RTKs), including ErbB2 and ErbB3. It is overexpressed in …