Purpose Psychiatric and behavioral side effects (PBSEs) are common, undesirable effects
associated with antiepileptic drug (AED) use. The objective of the study was to compare the …

The developmental and epileptic encephalopathies encompass a group of rare syndromes
characterised by severe drug-resistant epilepsy with onset in childhood and significant …

Purpose To understand the currently available post-marketing real-world evidence of the
incidences of and discontinuations due to the BAEs of irritability, anger, and aggression in …

Antiepileptic drugs (AEDs) are effective against seizures, but their use is often limited by
adverse effects, among them psychiatric and behavioral ones including aggressive behavior …

Glutamate is the brain's main excitatory neurotransmitter. Glutamatergic neurons primarily
compose basic neuronal networks, especially in the cortex. An imbalance of excitatory and …

Objective To pool observational data on the routine use of perampanel to obtain information
on real‐world outcomes and data in populations typically underrepresented in clinical trials …

Abstract Lennox-Gastaut syndrome (LGS), a childhood-onset severe developmental and
epileptic encephalopathy (DEE), is an entity that encompasses a heterogenous group of …

This retrospective study assessed long‐term effectiveness of add‐on perampanel (PER) in
patients with Lennox–Gastaut syndrome (LGS). Outcomes included time to PER failure and …

ABSTRACT Introduction: The alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid
(AMPA) receptors are the major mediators of glutamate-mediated excitatory …

Objective To assess the effectiveness and tolerability of perampanel (PER) monotherapy in
routine clinical practice for the treatment of focal onset and generalized tonic‐clonic seizures …