Molecular mechanisms of inflammation in sarcopenia: diagnosis and therapeutic update

GE Jimenez-Gutierrez, LE Martínez-Gómez… - Cells, 2022 - mdpi.com
Sarcopenia is generally an age-related condition that directly impacts the quality of life. It is
also related to chronic diseases such as metabolic dysfunction associated with diabetes and …

Recent progress in the analysis of unsaturated fatty acids in biological samples by chemical derivatization-based chromatography-mass spectrometry methods

C Chen, R Li, H Wu - Journal of Chromatography B, 2023 - Elsevier
Unsaturated fatty acids (UFAs) are essential fatty acids that execute various biological
functions in the human body. Therefore, the qualitative and quantitative analysis of UFAs in …

Associations between homocysteine, inflammatory cytokines and sarcopenia in Chinese older adults with type 2 diabetes

ZJ Mu, JL Fu, LN Sun, P Chan, SL Xiu - BMC geriatrics, 2021 - Springer
Background Sarcopenia, an age-related disease, has been implicated as both a cause and
consequence of type 2 diabetes mellitus (T2DM) and a symbol of poor prognosis in older …

Sarcopenia: investigation of metabolic changes and its associated mechanisms

J Marques, E Shokry, O Uhl, L Baber, F Hofmeister… - Skeletal Muscle, 2023 - Springer
Background Sarcopenia is one of the most predominant musculoskeletal diseases of the
elderly, defined as age-related progressive and generalized loss of muscle mass with a …

Deleterious effect of high-fat diet on skeletal muscle performance is prevented by high-protein intake in adult rats but not in old rats

E Poggiogalle, F Rossignon, A Carayon… - Frontiers in …, 2022 - frontiersin.org
The phenotype of sarcopenic obesity is frequently associated with impaired muscle strength
and performance. Ectopic lipid deposition may interfere with muscle anabolic response …

Metformin ameliorates skeletal muscle atrophy in Grx1 KO mice by regulating intramuscular lipid accumulation and glucose utilization

Y Yang, Z Liao, Q Xiao - Biochemical and Biophysical Research …, 2020 - Elsevier
Skeletal muscle is the largest tissue in the body, and plays a remarkable role in energy and
metabolic homeostasis. Disorder in lipid metabolism and glucose utilization could impair the …

[HTML][HTML] Combination of exercise training and resveratrol attenuates obese sarcopenia in skeletal muscle atrophy

CH Bai, J Alizargar, CY Peng… - Journal of Physiology …, 2020 - journals.lww.com
Obese sarcopenia is a progressive loss of skeletal muscle mass and strength with increases
in adipocytes. The aim of this study was to investigate the effects of combination of exercise …

Integrative cross-species analysis reveals conserved and unique signatures in fatty skeletal muscles

L Wang, Y Zhou, Y Wang, T Shan - Scientific Data, 2024 - nature.com
Fat infiltration in skeletal muscle is now recognized as a standard feature of aging and is
directly related to the decline in muscle function. However, there is still a limited systematic …

Sample preparation methods for lipidomics approaches used in studies of obesity

I Liakh, T Sledzinski, L Kaska, P Mozolewska, A Mika - Molecules, 2020 - mdpi.com
Obesity is associated with alterations in the composition and amounts of lipids. Lipids have
over 1.7 million representatives. Most lipid groups differ in composition, properties and …

Synergistic effects of oxidative and acid stress on bacterial membranes of Escherichia coli and Staphylococcus simulans

M Xie, EHW Koch, CA Walree, A Sobota… - Communications …, 2024 - nature.com
Oxidative stress in combination with acid stress has been shown to inactivate a wide
spectrum of microorganisms, including multi-resistant bacteria. This occurs eg in …