Older adults do not sleep as well as younger adults. Why? What alterations in sleep quantity
and quality occur as we age, and are there functional consequences? What are the …

The adenosine modulation system mostly operates through inhibitory A1 (A1R) and
facilitatory A2A receptors (A2AR) in the brain. The activity‐dependent release of adenosine …

This review covers the spatial and temporal rules governing induction of hippocampal long-
term potentiation (LTP) by theta-burst stimulation. Induction of LTP in field CA1 by high …

This review is focused on purinergic neurotransmission, ie, ATP released from nerves as a
transmitter or cotransmitter to act as an extracellular signaling molecule on both pre-and …

The decline observed during aging involves multiple factors that influence several systems.
It is the case for learning and memory processes which are severely reduced with aging. It is …

Aging is associated with cognitive decline and accumulation of senescent cells in various
tissues and organs. Senolytic agents such as dasatinib and quercetin (D+ Q) in combination …

The inhibitory adenosine A1 receptor (A1R) and excitatory A2A receptor (A2AR) are
predominantly expressed in the brain. Whereas the A2AR has been implicated in normal …

Progressive cognitive deficits that emerge with aging are a result of complex interactions of
genetic and environmental factors. Whereas much has been learned about the genetic …

The level of intracellular Ca2+ plays a central role in normal and pathological signaling
within and between neurons. These processes involve a cascade of events for locally …

Presynaptic spike timing-dependent long-term depression (t-LTD) at hippocampal CA3-CA1
synapses is evident until the 3rd postnatal week in mice, disappearing during the 4th week …