Brain glucose metabolism: integration of energetics with function

GA Dienel - Physiological reviews, 2019 - journals.physiology.org
Glucose is the long-established, obligatory fuel for brain that fulfills many critical functions,
including ATP production, oxidative stress management, and synthesis of neurotransmitters …

Physiology of astroglia

A Verkhratsky, M Nedergaard - Physiological reviews, 2018 - journals.physiology.org
Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …

Glia as sculptors of synaptic plasticity

L Sancho, M Contreras, NJ Allen - Neuroscience Research, 2021 - Elsevier
Glial cells are non-neuronal cells in the nervous system that are crucial for proper brain
development and function. Three major classes of glia in the central nervous system (CNS) …

Ion channels and electrophysiological properties of astrocytes: implications for emergent stimulation technologies

J McNeill, C Rudyk, ME Hildebrand… - Frontiers in Cellular …, 2021 - frontiersin.org
Astrocytes comprise a heterogeneous cell population characterized by distinct
morphologies, protein expression and function. Unlike neurons, astrocytes do not generate …

[HTML][HTML] Astrocyte-neuron circuits in epilepsy

BS Purnell, M Alves, D Boison - Neurobiology of disease, 2023 - Elsevier
The epilepsies are a diverse spectrum of disease states characterized by spontaneous
seizures and associated comorbidities. Neuron-focused perspectives have yielded an array …

Exciting complexity: the role of motor circuit elements in ALS pathophysiology

ZI Gunes, VWY Kan, XQ Ye, S Liebscher - Frontiers in neuroscience, 2020 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a fatal disease, characterized by the degeneration of
both upper and lower motor neurons. Despite decades of research, we still to date lack a …

[HTML][HTML] Good, bad, and neglectful: Astrocyte changes in neurodegenerative disease

Z Jiwaji, GE Hardingham - Free Radical Biology and Medicine, 2022 - Elsevier
Astrocytes play key roles in CNS development as well as well as neuro-supportive roles in
the mature brain including ionic, bioenergetic and redox homeostasis. Astrocytes undergo …

Astrocytes: the housekeepers and guardians of the CNS

A Verkhratsky, V Parpura, B Li, C Scuderi - Astrocytes in psychiatric …, 2021 - Springer
Astroglia are a diverse group of cells in the central nervous system. They are of the
ectodermal, neuroepithelial origin and vary in morphology and function, yet, they can be …

Roles of glial ion transporters in brain diseases

S Song, L Luo, B Sun, D Sun - Glia, 2020 - Wiley Online Library
Glial ion transporters are important in regulation of ionic homeostasis, cell volume, and
cellular signal transduction under physiological conditions of the central nervous system …

A tribute to Leif Hertz: The historical context of his pioneering studies of the roles of astrocytes in brain energy metabolism, neurotransmission, cognitive functions, and …

GA Dienel, A Schousboe, MC McKenna… - Journal of …, 2024 - Wiley Online Library
Abstract Leif Hertz, MD, D. Sc.(honōris causā)(1930–2018), was one of the original and
noteworthy participants in the International Conference on Brain Energy Metabolism …