The risk for major depression is both genetically and environmentally determined. It has
been proposed that epigenetic mechanisms could mediate the lasting increases in …

Recent advances in cell-type deconvolution approaches are adding to our understanding of
the biology underlying disease development and progression. DNA methylation (DNAm) …

Background There has been a long-standing need in biomedical research for a method that
quantifies the normally mixed composition of leukocytes beyond what is possible by simple …

Motivation: Recently there has been increasing interest in the effects of cell mixture on the
measurement of DNA methylation, specifically the extent to which small perturbations in cell …

Background Recent interest in reference-free deconvolution of DNA methylation data has
led to several supervised methods, but these methods do not easily permit the interpretation …

Whether Andean populations are genetically adapted to high altitudes has long been of
interest. Initial studies focused on physiological changes in the O2 transport system that …

Keratinocyte differentiation is an essential process for epidermal stratification and stratum
corneum formation. Keratinocytes proliferate in the basal layer of the epidermis and start …

Background Many different methods exist to adjust for variability in cell-type mixture
proportions when analyzing DNA methylation studies. Here we present the result of an …

DNA methylation (5-methylcytosine, 5-mC) is the best characterized epigenetic mark that
has regulatory roles in diverse biological processes. Recent investigation of RNA …

DNA methylation (DNAm) is known to play a pivotal role in childhood health and
development, but a comprehensive characterization of genome-wide DNAm trajectories …