Making sense of the ageing methylome
Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …
been associated with a broad range of age-related diseases, including cardiovascular …
Epigenome-wide association studies: current knowledge, strategies and recommendations
The aetiology and pathophysiology of complex diseases are driven by the interaction
between genetic and environmental factors. The variability in risk and outcomes in these …
between genetic and environmental factors. The variability in risk and outcomes in these …
Longitudinal multi-omics reveals subset-specific mechanisms underlying irritable bowel syndrome
The gut microbiome has been implicated in multiple human chronic gastrointestinal (GI)
disorders. Determining its mechanistic role in disease has been difficult due to apparent …
disorders. Determining its mechanistic role in disease has been difficult due to apparent …
Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays
Abstract Motivation: The recently released Infinium HumanMethylation450 array (the
'450k'array) provides a high-throughput assay to quantify DNA methylation (DNAm) at∼ 450 …
'450k'array) provides a high-throughput assay to quantify DNA methylation (DNAm) at∼ 450 …
Accounting for cellular heterogeneity is critical in epigenome-wide association studies
AE Jaffe, RA Irizarry - Genome biology, 2014 - Springer
Background Epigenome-wide association studies of human disease and other quantitative
traits are becoming increasingly common. A series of papers reporting age-related changes …
traits are becoming increasingly common. A series of papers reporting age-related changes …
ChAMP: 450k chip analysis methylation pipeline
TJ Morris, LM Butcher, A Feber, AE Teschendorff… - …, 2014 - academic.oup.com
Abstract The Illumina Infinium HumanMethylation450 BeadChip is a new platform for high-
throughput DNA methylation analysis. Several methods for normalization and processing of …
throughput DNA methylation analysis. Several methods for normalization and processing of …
Mapping DNA methylation across development, genotype and schizophrenia in the human frontal cortex
DNA methylation (DNAm) is important in brain development and is potentially important in
schizophrenia. We characterized DNAm in prefrontal cortex from 335 non-psychiatric …
schizophrenia. We characterized DNAm in prefrontal cortex from 335 non-psychiatric …
Functional normalization of 450k methylation array data improves replication in large cancer studies
We propose an extension to quantile normalization that removes unwanted technical
variation using control probes. We adapt our algorithm, functional normalization, to the …
variation using control probes. We adapt our algorithm, functional normalization, to the …
A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data
Abstract Motivation: The Illumina Infinium 450 k DNA Methylation Beadchip is a prime
candidate technology for Epigenome-Wide Association Studies (EWAS). However, a …
candidate technology for Epigenome-Wide Association Studies (EWAS). However, a …
Statistical and integrative system-level analysis of DNA methylation data
AE Teschendorff, CL Relton - Nature Reviews Genetics, 2018 - nature.com
Epigenetics plays a key role in cellular development and function. Alterations to the
epigenome are thought to capture and mediate the effects of genetic and environmental risk …
epigenome are thought to capture and mediate the effects of genetic and environmental risk …