[HTML][HTML] Overcoming cancer therapeutic bottleneck by drug repurposing

Z Zhang, L Zhou, N Xie, EC Nice, T Zhang… - Signal transduction and …, 2020 - nature.com
Ever present hurdles for the discovery of new drugs for cancer therapy have necessitated
the development of the alternative strategy of drug repurposing, the development of old …

[HTML][HTML] Apoptosis: a target for anticancer therapy

CM Pfeffer, ATK Singh - International journal of molecular sciences, 2018 - mdpi.com
Apoptosis, the cell's natural mechanism for death, is a promising target for anticancer
therapy. Both the intrinsic and extrinsic pathways use caspases to carry out apoptosis …

Curcumin, a golden spice with a low bioavailability

A Siviero, E Gallo, V Maggini, L Gori, A Mugelli… - Journal of Herbal …, 2015 - Elsevier
In recent years several drugs have been developed deriving from traditional products and
current drug research is actively investigating the possible therapeutic roles of many …

Curcumin supplementation in pediatric patients: A systematic review of current clinical evidence

Z Heidari, M Daei, M Boozari… - Phytotherapy …, 2022 - Wiley Online Library
This systematic review was designed to determine the clinical efficacy and safety of
curcumin supplementation for pediatric patients based on clinical trials in children. We …

[HTML][HTML] Targeted therapies of curcumin focus on its therapeutic benefits in cancers and human health: Molecular signaling pathway-based approaches and future …

MR Islam, A Rauf, S Akash, SI Trisha, AH Nasim… - Biomedicine & …, 2024 - Elsevier
The curry powder spices turmeric (Curcuma longa L.), which contains curcumin
(diferuloylmethane), an orange-yellow chemical. Polyphenols are the most commonly used …

[HTML][HTML] Nanoparticle curcumin ameliorates experimental colitis via modulation of gut microbiota and induction of regulatory T cells

M Ohno, A Nishida, Y Sugitani, K Nishino, O Inatomi… - PloS one, 2017 - journals.plos.org
Background and Aims Curcumin is a hydrophobic polyphenol derived from turmeric, a
traditional Indian spice. Curcumin exhibits various biological functions, but its clinical …

Curcumin and cancer: barriers to obtaining a health claim

JG Devassy, ID Nwachukwu, PJH Jones - Nutrition reviews, 2015 - academic.oup.com
Curcumin is a highly pleiotropic molecule found in the rhizomes of Curcuma longa
(turmeric). It is responsible for the yellow color of turmeric and has been shown to inhibit the …

Cancer chemoprevention by dietary phytochemicals: Epidemiological evidence

RB Ruiz, PS Hernández - Maturitas, 2016 - Elsevier
Background In recent years, natural compounds called “phytochemicals”, which are present
in fruits, vegetables, and plants, have received special attention due to their potential to …

[HTML][HTML] Evaluation of curcumin loaded chitosan/PEG blended PLGA nanoparticles for effective treatment of pancreatic cancer

G Arya, M Das, SK Sahoo - Biomedicine & Pharmacotherapy, 2018 - Elsevier
Pancreatic cancer is considered as one of the most lethal type of cancer with a poor 5-year
survival rate. Cancer metastasis represents one of the primary cause which limits therapy …

Phytosome complex of curcumin as complementary therapy of advanced pancreatic cancer improves safety and efficacy of gemcitabine: Results of a prospective …

D Pastorelli, ASC Fabricio, P Giovanis… - Pharmacological …, 2018 - Elsevier
A large body of biomedical evidence indicates that activation of Nrf2 by curcumin increases
the nucleophilic tone and damps inflammation cumulatively supporting the malignant …