Aspects of the tumor microenvironment involved in immune resistance and drug resistance

K Khalaf, D Hana, JTT Chou, C Singh… - Frontiers in …, 2021 - frontiersin.org
The tumor microenvironment (TME) is a complex and ever-changing “rogue organ”
composed of its own blood supply, lymphatic and nervous systems, stroma, immune cells …

The potential use of mesenchymal stem cells and their exosomes in Parkinson's disease treatment

RM Heris, M Shirvaliloo, S Abbaspour-Aghdam… - Stem Cell Research & …, 2022 - Springer
Parkinson's disease (PD) is the second most predominant neurodegenerative disease
worldwide. It is recognized clinically by severe complications in motor function caused by …

Single-cell, whole-embryo phenotyping of mammalian developmental disorders

X Huang, J Henck, C Qiu, VKA Sreenivasan… - Nature, 2023 - nature.com
Mouse models are a critical tool for studying human diseases, particularly developmental
disorders. However, conventional approaches for phenotyping may fail to detect subtle …

Intranasal delivery of mesenchymal stem cells-derived extracellular vesicles for the treatment of neurological diseases

S Herman, I Fishel, D Offen - Stem Cells, 2021 - academic.oup.com
Neurological disorders are diseases of the central nervous system (CNS), characterized by
a progressive degeneration of cells and deficiencies in neural functions. Mesenchymal stem …

Chromatin remodeling due to degradation of citrate carrier impairs osteogenesis of aged mesenchymal stem cells

A Pouikli, S Parekh, M Maleszewska, C Nikopoulou… - Nature Aging, 2021 - nature.com
Aging is accompanied by a general decline in the function of many cellular pathways.
However, whether these are causally or functionally interconnected remains elusive. Here …

Therapeutic application of mesenchymal stem cells derived exosomes in neurodegenerative diseases: a focus on non-coding RNAs cargo, drug delivery potential …

M Hedayat, M Ahmadi, M Shoaran, J Rezaie - Life Sciences, 2023 - Elsevier
Despite the massive efforts advanced over recent years in emerging therapies for
neurodegenerative diseases, effective treatment for these diseases is still an urgent need …

Oxidative stress‐a direct bridge to central nervous system homeostatic dysfunction and Alzheimer's disease

MM Anwar - Cell biochemistry and function, 2022 - Wiley Online Library
Neurologists have highly observed a frequent increasing number of elderly patients with
Alzheimer's disease (AD) without any relevant evidence of any genetic or known AD‐linked …

Stem cells and extrusion 3D printing for hyaline cartilage engineering

O Messaoudi, C Henrionnet, K Bourge, D Loeuille… - Cells, 2020 - mdpi.com
Hyaline cartilage is deficient in self-healing properties. The early treatment of focal cartilage
lesions is a public health challenge to prevent long-term degradation and the occurrence of …

Enhancing stem cell-based therapeutic potential by combining various bioengineering technologies

IS Hong - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
Stem cell-based therapeutics have gained tremendous attention in recent years due to their
wide range of applications in various degenerative diseases, injuries, and other health …

The evolving regulatory landscape in regenerative medicine

DJ Beetler, DN Di Florio, EW Law, CM Groen… - Molecular aspects of …, 2023 - Elsevier
Regenerative medicine as a field has emerged as a new component of modern medicine
and medical research that encompasses a wide range of products including cellular and …