KRAS‐G12D mutation drives immune suppression and the primary resistance of anti‐PD‐1/PD‐L1 immunotherapy in non‐small cell lung cancer
C Liu, S Zheng, Z Wang, S Wang, X Wang… - Cancer …, 2022 - Wiley Online Library
Background Although immune checkpoint inhibitors (ICIs) against programmed cell death
protein 1 (PD‐1) and its ligand PD‐L1 have demonstrated potency towards treating patients …
protein 1 (PD‐1) and its ligand PD‐L1 have demonstrated potency towards treating patients …
Plasma cell signatures predict prognosis and treatment efficacy for lung adenocarcinoma
L Shu, J Tang, S Liu, Y Tao - Cellular Oncology, 2024 - Springer
Purpose This study aims to identify key genes regulating tumor infiltrating plasma cells (PC)
and provide new insights for innovative immunotherapy. Methods: Key genes related to PC …
and provide new insights for innovative immunotherapy. Methods: Key genes related to PC …
[HTML][HTML] Identification of novel gene signature for lung adenocarcinoma by machine learning to predict immunotherapy and prognosis
J Shu, J Jiang, G Zhao - Frontiers in Immunology, 2023 - frontiersin.org
Background Lung adenocarcinoma (LUAD) as a frequent type of lung cancer has a 5-year
overall survival rate of lower than 20% among patients with advanced lung cancer. This …
overall survival rate of lower than 20% among patients with advanced lung cancer. This …
[HTML][HTML] Tumor immune microenvironment of self-identified African American and non-African American triple negative breast cancer
Differences in the tumor immune microenvironment may result in differences in prognosis
and response to treatment in cancer patients. We hypothesized that differences in the tumor …
and response to treatment in cancer patients. We hypothesized that differences in the tumor …
Compositional and structural characterization of dorsal root ganglion neurons and co-cultured Schwann cells by confocal Raman microspectral imaging
J Li - Vibrational Spectroscopy, 2024 - Elsevier
Confocal Raman microspectral imaging (CRMI) is a versatile non-invasive technique that
allows in vitro cell imaging without any chemical fixation, fluorescent markers or other …
allows in vitro cell imaging without any chemical fixation, fluorescent markers or other …
Dexamethasone Pretreatment Potentiates a Folic Acid-Functionalized Delivery System for Enhanced Lung Cancer Therapy
Y Zhao, C Jia, Z Yao, G Chen, G Huang… - Molecular …, 2024 - ACS Publications
Folic acid (FA) has been widely engineered to promote the targeted delivery of FA-modified
nanoparticles (NPs) by recognizing the folate receptor α (FRα). However, the efficacy of FA …
nanoparticles (NPs) by recognizing the folate receptor α (FRα). However, the efficacy of FA …
[HTML][HTML] MFI2 upregulation promotes malignant progression through EGF/FAK signaling in oral cavity squamous cell carcinoma
WC Yen, KP Chang, CY Chen, Y Huang… - Cancer Cell …, 2023 - Springer
Oral squamous cell carcinoma (OSCC) is the predominant histological type of the head and
neck squamous cell carcinoma (HNSCC). By comparing the differentially expressed genes …
neck squamous cell carcinoma (HNSCC). By comparing the differentially expressed genes …
The E2F1/MELTF axis fosters the progression of lung adenocarcinoma by regulating the Notch signaling pathway
L Zhang, L Shi - … Research/Fundamental and Molecular Mechanisms of …, 2023 - Elsevier
Background Lung adenocarcinoma (LUAD) represents the predominant subtype of lung
cancer. MELTF, an oncogene, exhibits high expression in various cancer tissues …
cancer. MELTF, an oncogene, exhibits high expression in various cancer tissues …
The role of Transferrin 2 and Laminin B2 in Drosophila melanogaster intestinal stem cell homeostasis and ageing
A GALBRAITH - 2024 - etheses.dur.ac.uk
Ageing is accompanied by many physiological changes. This is particularly evident in the
intestine, where changes in gene expression, gut barrier, and microbiome pre-empt disease …
intestine, where changes in gene expression, gut barrier, and microbiome pre-empt disease …