Spatial analysis of drug absorption, distribution, metabolism, and toxicology using mass spectrometry imaging

ML Spruill, M Maletic-Savatic, H Martin, F Li… - Biochemical …, 2022 - Elsevier
Mass spectrometry imaging (MSI) is emerging as a powerful analytical tool for detection,
quantification, and simultaneous spatial molecular imaging of endogenous and exogenous …

Safety and tolerability of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in oncology

RR Shah, DR Shah - Drug safety, 2019 - Springer
Tyrosine kinase inhibitors (TKIs) that target epidermal growth factor receptor (EGFR) have
dramatically improved progression-free survival in non-small-cell lung cancer (NSCLC) …

Next‐generation pathology practices with mass spectrometry imaging

HH Chung, P Huang, CL Chen, C Lee… - Mass Spectrometry …, 2023 - Wiley Online Library
Mass spectrometry imaging (MSI) is a powerful technique that reveals the spatial distribution
of various molecules in biological samples, and it is widely used in pathology‐related …

Quantitative mass spectrometry imaging reveals mutation status-independent lack of imatinib in liver metastases of gastrointestinal stromal tumors

D Abu Sammour, C Marsching, A Geisel, K Erich… - Scientific reports, 2019 - nature.com
Mass spectrometry imaging (MSI) is an enabling technology for label-free drug disposition
studies at high spatial resolution in life science-and pharmaceutical research. We present …

MALDI-MSI analysis of cancer drugs: Significance, advances, and applications

Q He, C Sun, J Liu, Y Pan - TrAC Trends in Analytical Chemistry, 2021 - Elsevier
Because of the heterogeneity and complexity of tumor structure, cancer drugs often cannot
effectively reach the tumor, which is one of the reasons for drug resistance and treatment …

The space dimension at the micro level: mass spectrometry imaging of drugs in tissues

E Davoli, M Zucchetti, C Matteo… - Mass spectrometry …, 2021 - Wiley Online Library
Mass spectrometry imaging (MSI) has seen remarkable development in recent years. The
possibility of getting quantitative or semiquantitative data, while maintaining the spatial …

Precision pharmacology: Mass spectrometry imaging and pharmacokinetic drug resistance

M Jove, J Spencer, M Clench, PM Loadman… - Critical reviews in …, 2019 - Elsevier
Failure of systemic cancer treatment can be, at least in part, due to the drug not being
delivered to the tumour at sufficiently high concentration and/or sufficiently homogeneous …

Imaging and quantifying drug delivery in skin–part 1: Autoradiography and mass spectrometry imaging

S Grégoire, GS Luengo, P Hallegot, AM Pena… - Advanced Drug Delivery …, 2020 - Elsevier
In this two-part review we present an up-to-date description of different imaging methods
available to map the localization of drugs on skin as a complement of established ex-vivo …

Spatial mapping of cancer tissues by OMICS technologies

R Ahmed, R Augustine, E Valera, A Ganguli… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Spatial mapping of heterogeneity in gene expression in cancer tissues can improve our
understanding of cancers and help in the rapid detection of cancers with high accuracy and …

Comparative study on the efficacy and exposure of molecular target agents in non–small cell lung cancer PDX models with driver genetic alterations

H Jo, S Yagishita, Y Hayashi, S Ryu, M Suzuki… - Molecular Cancer …, 2022 - AACR
Patient-derived xenografts (PDX) can adequately reflect clinical drug efficacy. However, the
methods for evaluating drug efficacy are not fully established. We selected five non–small …