Targeting the dopaminergic system in autoimmunity

PM Vidal, R Pacheco - Journal of Neuroimmune Pharmacology, 2020 - Springer
Dopamine has emerged as a fundamental regulator of inflammation. In this regard, it has
been shown that dopaminergic signalling pathways are key players promoting homeostasis …

Dopamine receptor D3 signaling on CD4+ T cells favors Th1-and Th17-mediated immunity

F Contreras, C Prado, H González, D Franz… - The Journal of …, 2016 - journals.aai.org
Abstract Dopamine receptor D3 (DRD3) expressed on CD4+ T cells is required to promote
neuroinflammation in a murine model of Parkinson's disease. However, how DRD3 …

Role of neurochemicals in the interaction between the microbiota and the immune and the nervous system of the host organism

AV Oleskin, BA Shenderov, VS Rogovsky - Probiotics and Antimicrobial …, 2017 - Springer
This work is concerned with the role of evolutionary conserved substances,
neurotransmitters, and neurohormones, within the complex framework of the microbial …

Who knew? Dopamine transporter activity is critical in innate and adaptive immune responses

A Gopinath, PM Mackie, LT Phan, R Mirabel, AR Smith… - Cells, 2023 - mdpi.com
The dopamine transporter (DAT) regulates the dimension and duration of dopamine
transmission. DAT expression, its trafficking, protein–protein interactions, and its activity are …

The association between the neuroendocrine system and the tumor immune microenvironment: emerging directions for cancer immunotherapy

J Li, M Che, B Zhang, K Zhao, C Wan, K Yang - Biochimica et Biophysica …, 2023 - Elsevier
This review summarizes emerging evidence that the neuroendocrine system is involved in
the regulation of the tumor immune microenvironment (TIME) to influence cancer …

The role of regulatory T cells in neurodegenerative diseases

F He, R Balling - Wiley Interdisciplinary Reviews: Systems …, 2013 - Wiley Online Library
A sustained neuroinflammatory response is the hallmark of many neurodegenerative
diseases, including Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis …

The dopaminergic system in peripheral blood lymphocytes: from physiology to pharmacology and potential applications to neuropsychiatric disorders

FR Buttarelli, A Fanciulli, C Pellicano… - Current …, 2011 - ingentaconnect.com
Besides its action on the nervous system, dopamine (DA) plays a role on neural-immune
interactions. Here we review the current evidence on the dopaminergic system in human …

Synaptic interactions in germinal centers

I Papa, CG Vinuesa - Frontiers in immunology, 2018 - frontiersin.org
The germinal center (GC) is a complex, highly dynamic microanatomical niche that allows
the generation of high-affinity antibody-producing plasma cells and memory B cells. These …

[HTML][HTML] Stem cell regulation via dynamic interactions of the nervous and immune systems with the microenvironment

A Spiegel, A Kalinkovich, S Shivtiel, O Kollet, T Lapidot - Cell stem cell, 2008 - cell.com
Physiological interactions between the nervous and immune systems with components of
the local microenvironment are needed to maintain homeostasis throughout the body …

Combined exercise training reduces fatigue and modulates the cytokine profile of T-cells from multiple sclerosis patients in response to neuromediators

H Alvarenga-Filho, PM Sacramento, TB Ferreira… - Journal of …, 2016 - Elsevier
Fatigue is a common and disabling symptom of multiple sclerosis (MS), a classical Th1-and
Th17-mediated autoimmune disease. There is no effective pharmacological treatment for …