Mast cells are important first responders in protective pain responses that provoke
withdrawal from intense, noxious environmental stimuli, in part because of their sentinel …

Alopecia areata (AA) is a CD8+ T-cell dependent autoimmune disease of the hair follicle
(HF) in which the collapse of HF immune privilege (IP) plays a key role. Mast cells (MCs) are …

Pain is among the most widespread chronic health condition confronting society today and
our inability to manage chronic pain contributes to the opioid abuse epidemic in America …

Decreased activity of catechol-O-methyltransferase (COMT), an enzyme that metabolizes
catecholamines, contributes to pain in humans and animals. Previously, we demonstrated …

Increasing evidence suggests that cytokines and chemokines play crucial roles in chronic
itch. In the present study, we evaluated the roles of tumor necrosis factor-alpha (TNF-α) and …

Mechanical allodynia is a debilitating condition for millions of patients with chronic pain.
Mechanical allodynia can manifest in distinct forms, including brush-evoked dynamic and …

The interplay among pain, allergy and dysregulated inflammation promises to yield
significant conceptual advances in immunology and chronic pain. Hapten-mediated contact …

Researches of recent past years have emphasized potential of antibiotics to improve septic
arthritis but as multi-drug resistant strains like MRSA are emerging fast, new alternative …

Background Recent studies report infiltration of peripheral blood mononuclear cells
(PBMCs) into the central nervous system (CNS) in epileptic disorders, suggestive of a …

Aims: To determine the involvement of tumor necrosis factor alpha (TNFα) signaling in the
trigeminal ganglion (TG) in the mechanical hypersensitivity of the masseter muscle during …