Our understanding of diabetes mellitus has benefited from a combination of clinical
investigations and work in model organisms and cell lines. Organoid models for a wide …

This review is an account of methods that use various strategies to control microfluidic flow
control with high accuracy. The reviewed systems are divided into two large groups based …

Conventional preclinical evaluation implemented in 2D monolayer cultures falls short with
multiorgan interactions, while animal systems lack the specificity of the human species …

Type 1 diabetes mellitus (T1DM) is the most common autoimmune chronic disease in young
patients. It is caused by the destruction of pancreatic endocrine β-cells that produce insulin …

Microfluidic organs and organoids-on-a-chip models of human gastrointestinal systems
have been established to recreate adequate microenvironments to study physiology and …

Organ-on-a-chip (OoC) is a new and promising technology, which aims to improve the
efficiency of drug development and realize personalized medicine by simulating in vivo …

Diabetes mellitus (DM) is a very serious disease, the incidence of which has been
increasing worldwide. The beginning of diabetic research can be traced back to the 17th …

Metabolic diseases have been a major public health issue and a clinical challenge
worldwide. Dysfunction of metabolic homeostasis is linked to the onset of various diseases …

The ever greater understanding of the composition and function of the gut microbiome has
provided new opportunities with respect to understanding and treating human disease …

Since every biological system requires capillaries to support its oxygenation, design of
engineered preclinical models of such systems, for example, vascularized …