Precision medicine in complex diseases—Molecular subgrouping for improved prediction and treatment stratification

Å Johansson, OA Andreassen, S Brunak… - Journal of internal …, 2023 - Wiley Online Library
Complex diseases are caused by a combination of genetic, lifestyle, and environmental
factors and comprise common noncommunicable diseases, including allergies …

Epigenome-wide association analysis of infant bronchiolitis severity: a multicenter prospective cohort study

Z Zhu, Y Li, RJ Freishtat, JC Celedón… - Nature …, 2023 - nature.com
Bronchiolitis is the most common lower respiratory infection in infants, yet its pathobiology
remains unclear. Here we present blood DNA methylation data from 625 infants hospitalized …

The role of DNA methylation in personalized medicine for immune-related diseases

MK Gupta, H Peng, Y Li, CJ Xu - Pharmacology & Therapeutics, 2023 - Elsevier
Epigenetics functions as a bridge between host genetic & environmental factors, aiding in
human health and diseases. Many immune-related diseases, including infectious and …

Current state and prospects of artificial intelligence in allergy

M van Breugel, RSN Fehrmann, M Bügel, FI Rezwan… - Allergy, 2023 - Wiley Online Library
The field of medicine is witnessing an exponential growth of interest in artificial intelligence
(AI), which enables new research questions and the analysis of larger and new types of …

[HTML][HTML] Epigenome-wide association studies of allergic disease and the environment

A Cardenas, RP Fadadu, GH Koppelman - Journal of Allergy and Clinical …, 2023 - Elsevier
The epigenome is at the intersection of the environment, genotype, and cellular response.
DNA methylation of cytosine nucleotides, the most studied epigenetic modification, has been …

Exploring Artificial Intelligence in Evolving Healthcare Environments: A Comprehensive Analysis

R Barua - Advances in Computational Intelligence for the …, 2024 - igi-global.com
Artificial intelligence (AI) is assuming an increasingly significant role in our daily lives,
primarily due to the array of benefits it offers when applied. These advantages encompass …

[HTML][HTML] Associations of co-exposure to polycyclic aromatic hydrocarbons and lead (Pb) with IGF1 methylation in peripheral blood of preschool children from an e …

X Huo, X Xu, Q Wang, J Zhang, MN Hylkema… - Environment …, 2024 - Elsevier
Background Childhood exposure to polycyclic aromatic hydrocarbons (PAHs) or lead (Pb) is
associated with epigenetic modifications. However, the effects of their co-exposures on IGF1 …

Uncovering the Cellular Microenvironment in Chronic Rhinosinusitis via Single-Cell RNA Sequencing: Application and Future Directions

Y Liu, W Lv, W Wang - Clinical Reviews in Allergy & Immunology, 2024 - Springer
Chronic rhinosinusitis (CRS) is a heterogenic disease characterized by persistent mucosal
inflammation of the upper airway. Researches of CRS have progressed from phenotype …

Multimorbidities in Allergic Rhinitis—Current Evidence from Epidemiological Studies, Treatment Trials, and Molecular Data

IM Vlastos, Z Kalentakis, M Doulaptsi… - Current Allergy and …, 2023 - Springer
Abstract Purpose of Review Given that allergic rhinitis (AR) commonly coexists with other
diseases, the present narrative review attempts a brief presentation of current theories on …

Epigenomic insights into common human disease pathology

CG Bell - Cellular and Molecular Life Sciences, 2024 - Springer
The epigenome—the chemical modifications and chromatin-related packaging of the
genome—enables the same genetic template to be activated or repressed in different …