Genome architecture has proven to be critical in determining gene regulation across almost
all domains of life. While many of the key components and mechanisms of eukaryotic …

Heterochromatin is most often associated with eukaryotic organisms. Yet, bacteria also
contain areas with densely protein-occupied chromatin that appear to silence gene …

Abstract The Sm protein Hfq chaperones small non-coding RNAs (sRNAs) in bacteria,
facilitating sRNA regulation of target mRNAs. Hfq acts in part by remodeling the sRNA and …

RNA-binding proteins play myriad roles in regulating RNAs and RNA-mediated functions. In
bacteria, the RNA chaperone Hfq is an important post-transcriptional gene regulator. Using …

The bacterial chromosomic DNA is packed within a membrane-less structure, the nucleoid,
due to the association of DNA with proteins called Nucleoid Associated Proteins (NAPs) …

Hfq is required by many Gram-negative bacteria to chaperone the interaction between small
non-coding RNA (sRNA) and mRNA to facilitate annealing. Conversely and despite the …

The widely occurring bacterial RNA chaperone Hfq is a key factor in the post‐transcriptional
control of hundreds of genes in Pseudomonas aeruginosa. How this broadly acting protein …

Hfq is a pleiotropic regulator that mediates several aspects of bacterial RNA metabolism.
The protein notably regulates translation efficiency and RNA decay in Gram-negative …

There is increasing evidence that prokaryotes maintain chromosome structure, which in turn
impacts gene expression. We recently characterized densely occupied, multi‐kilobase …

Hfq is a pleitropic actor that serves as stress response and virulence factor in the bacterial
cell. To execute its multiple functions, Hfq assembles into symmetric torus-shaped …