Lipid droplets (also known as lipid bodies) are lipid-rich, cytoplasmic organelles that play
important roles in cell signaling, lipid metabolism, membrane trafficking, and the production …

Metabolic reprogramming is widely observed during cancer development to confer cancer
cells the ability to survive and proliferate, even under the stressed, such as nutrient-limiting …

Hypoxia-inducible factor (HIF) is a main heterodimeric transcription factor that regulates the
cellular adaptive response to hypoxia by stimulating the transcription of a series of hypoxia …

Oxidative stress has been increasingly recognized as a major contributing factor in a variety
of human diseases, from inflammation to cancer. Although certain parts of signaling …

Increasing recognition of an association between obesity and many cancer types exists, but
how the myriad of local and systemic effects of obesity affect key cellular and non-cellular …

The sex-determining region Y (SRY)-box (SOX) family has a crucial role in carcinogenesis
and cancer progression. However, the role of SOX12 and the mechanism by which it is …

Gastric cancer is a common malignancy with high mortality and limited therapeutic options.
Hypoxia inducible factor-1 α (HIF-1α) is the key responser adapted to tumor hypoxia. Under …

Immune checkpoint inhibitors (ICIs), Ipilimumab, Nivolumab, Pembrolizumab and
Atezolizumab, have been applied in anti-tumor therapy and demonstrated exciting …

Simple Summary Deregulated cellular metabolism is one of the major hallmarks of cancer.
Cancer cells orchestrate abnormal metabolic reprogramming to satisfy high energy …

Purpose Previously, inflammation has been found to be associated with the development of
lung cancer. Despite their well-characterized pro-inflammatory functions, the putative roles …