Hypoxia-inducible factor 1α (HIF1α) has been demonstrated to be involved in the resistance
of various human cancer cells to chemotherapies. However, correlation between HIF1α and …

Background Long-term hypoxia (LTH) is an important stressor related to health and disease
during development. At different time points from fetus to adult, we are exposed to hypoxic …

Neoplastic cells display altered biosynthetic and bioenergetic machinery to support cell
survival. Therefore, cancer cells optimally utilize all available fuel resources to pump their …

Gestational hypoxia is a risk factor in the development of pulmonary hypertension in the
newborn and other sequela, however, the mechanisms associated with the disease remain …

Hypoxic conditions in various cancers are believed to relate with their malignancy, and
hypoxia inducible factor-1α (HIF-1α) has been shown to be a major regulator of the …

Background: Ovarian cancer (OV) is a prevalent malignancy among gynecological tumors.
Numerous metabolic pathways play a significant role in various human diseases, including …

We performed a comprehensive quantification of 20 amino acids in RPMI 1640 medium-
cultured human colorectal adenocarcinoma cells to evaluate the efficacy of 5-fluorouracil …

Metabolic reprogramming, such as abnormal utilization of glucose, addiction to glutamine,
and increased de-novo lipid synthesis, extensively occurs in proliferating cancer cells, but …

A brief overview of the most well-known seven types of carcinogenesis models is presented.
They include mutation models, genomic instability models, non-genotoxic models …

At a cellular level, nutrients are sensed by the mechanistic Target of Rapamycin (mTOR).
The response of cells to hypoxia is regulated via action of the oxygen sensor Hypoxia …