Free radical damage in ischemia‐reperfusion injury: an obstacle in acute ischemic stroke after revascularization therapy

MS Sun, H Jin, X Sun, S Huang… - Oxidative medicine …, 2018 - Wiley Online Library
Acute ischemic stroke is a common cause of morbidity and mortality worldwide.
Thrombolysis with recombinant tissue plasminogen activator and endovascular …

Remote ischaemic conditioning—a new paradigm of self-protection in the brain

DC Hess, RA Blauenfeldt, G Andersen… - Nature Reviews …, 2015 - nature.com
Remote ischaemic conditioning (RIC) triggers endogenous protective pathways in distant
organs such as the kidney, heart and brain, and represents an exciting new paradigm in …

Upper limb ischemic preconditioning prevents recurrent stroke in intracranial arterial stenosis

R Meng, K Asmaro, L Meng, Y Liu, C Ma, C Xi, G Li… - Neurology, 2012 - AAN Enterprises
Objective: This study aims to evaluate protective effects of brief repetitive bilateral arm
ischemic preconditioning (BAIPC) on stroke recurrence in patients with symptomatic …

Protecting the ischaemic penumbra as an adjunct to thrombectomy for acute stroke

JC Baron - Nature Reviews Neurology, 2018 - nature.com
After ischaemic stroke, brain damage can be curtailed by rescuing the 'ischaemic penumbra'—
that is, the severely hypoperfused, at-risk but not yet infarcted tissue. Current evidence …

Remote ischemic perconditioning as an adjunct therapy to thrombolysis in patients with acute ischemic stroke: a randomized trial

KD Hougaard, N Hjort, D Zeidler, L Sørensen… - Stroke, 2014 - Am Heart Assoc
Background and Purpose—Remote ischemic preconditioning is neuroprotective in models
of acute cerebral ischemia. We tested the effect of prehospital rPerC as an adjunct to …

Neuroprotection for ischaemic stroke: current status and challenges

A Moretti, F Ferrari, RF Villa - Pharmacology & therapeutics, 2015 - Elsevier
Stroke is the third cause of death worldwide and the main cause of chronic, severe adult
disability. We focus on acute ischaemic stroke, which accounts for approximately 80% of all …

[HTML][HTML] Potential neuroprotective treatment of stroke: targeting excitotoxicity, oxidative stress, and inflammation

Q Yang, Q Huang, Z Hu, X Tang - Frontiers in neuroscience, 2019 - frontiersin.org
Stroke is a major cause of death and adult disability. However, therapeutic options remain
limited. Numerous pathways underlie acute responses of brain tissue to stroke. Early events …

[HTML][HTML] Preactivation of Notch1 in remote ischemic preconditioning reduces cerebral ischemia-reperfusion injury through crosstalk with the NF-κB pathway

W Liang, C Lin, L Yuan, L Chen, P Guo, P Li… - Journal of …, 2019 - Springer
Background Remote ischemic preconditioning (RIPC) initiates endogenous protective
pathways in the brain from a distance and represents a new, promising paradigm in …

[HTML][HTML] Ischemic conditioning is safe and effective for octo-and nonagenarians in stroke prevention and treatment

R Meng, Y Ding, K Asmaro, D Brogan, L Meng, M Sui… - …, 2015 - Elsevier
Symptomatic intracranial arterial stenosis (SIAS) is very common in octo-and
nonagenarians, especially in the Chinese population, and is likely the most common cause …

Effect of in-hospital remote ischemic perconditioning on brain infarction growth and clinical outcomes in patients with acute ischemic stroke: the RESCUE BRAIN …

F Pico, B Lapergue, M Ferrigno, C Rosso… - JAMA …, 2020 - jamanetwork.com
Importance Treatment with remote ischemic perconditioning has been reported to reduce
brain infarction volume in animal models of stroke. Whether this neuroprotective effect was …