In 1993, Przyklenk and colleagues made the intriguing experimental observation that 'brief
ischemia in one vascular bed also protects remote, virgin myocardium from subsequent …

Stroke remains one of the most common causes of death and disability worldwide. Several
preclinical studies demonstrated that the brain can be effectively protected against …

Background and Purpose—Remote ischemic conditioning is cardioprotective in myocardial
infarction and neuroprotective in mechanical occlusion models of stroke. However, there is …

In the area of brain injury and neurodegenerative diseases, a plethora of experimental and
clinical evidence strongly indicates the promise of therapeutically exploiting the endogenous …

Human performance, endurance, and resilience have biological limits that are genetically
and epigenetically predetermined but perhaps not yet optimized. There are few systematic …

Novel and innovative approaches are essential in developing new treatments and improving
clinical outcomes in patients with ischemic stroke. Remote ischemic conditioning (RIC) is a …

Organ or tissue dysfunction due to acute ischemia–reperfusion injury (IRI) is the leading
cause of death and disability worldwide. Acute IRI induces cell injury and death in a wide …

Ischemic exercise conducted as low-load blood flow restricted resistance exercise (BFRE)
can lead to muscle remodelling and promote muscle growth, possibly through activation of …

These preclinical findings launched a number of randomized clinical trials of remote limb
preconditioning to protect the heart. In a meta-analysis of 23 randomized clinical trials of …

Autophagy, an important intracellular degradation pathway, has been reported to clear
impaired mitochondria and reduce mitochondria-mediated injury in ischemic disease. Our …